The role of SERPIND1 gene in the development of breast cancer is completely unknown. The aim of the present study was to assess the expression of SERPIND1 in patients suffering from breast malignancies. Tumoural specimens and non-tumoural adjacent tissues were collected from 31 patients who were pathologically confirmed for breast cancer. Furthermore, 43 fasting venous blood samples were collected from the breast cancer patients as well as from the healthy volunteers as control group. The SERPIND1 mRNA expression levels were assessed using the q-RT PCR while the plasma levels of SERPIND1 protein were detected using ELISA. The SERPIND1 relative expression levels were compared with the clinicopathological factors. The expression of the SERPIND1 was significantly higher at both mRNA and protein levels in breast cancer patients compared to the control groups. Moreover, the relative expression of the SERPIND1 showed a significant positive correlation with cancer grade, stage and presence of metastasis (P< 0.05). The findings suggest that the SERPIND1 may be a metastasis-enhancer factor in breast cancer and a strong predictive marker for distinguishing patients with poor prognosis.

中文翻译：

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SERPIND1表达与乳腺癌的分级，分期和转移的关系

的作用SERPIND1基因在乳腺癌的发展是完全陌生的。本研究的目的是评估SERPIND1在乳腺恶性肿瘤患者中的表达。从31例经病理证实为乳腺癌的患者中收集肿瘤标本和非肿瘤性邻近组织。此外，从乳腺癌患者以及作为对照组的健康志愿者中收集了43个空腹静脉血样品。所述SERPIND1的mRNA表达水平，同时的血浆水平使用Q-RT PCR评估SERPIND1使用ELISA法检测蛋白。该SERPIND1将相对表达水平与临床病理因素进行比较。与对照组相比，乳腺癌患者中SERPIND1的表达在mRNA和蛋白水平上均显着较高。此外，SERPIND1的相对表达与癌的分级，分期和转移的发生呈显着正相关（P <0.05）。这些发现表明SERPIND1可能是乳腺癌的转移增强因子，并且是区分预后差的强预测指标。