Role of endothelium glycocalyx integraty is important for targeted intravenous nanoparticle drug delivery. It plays a vital role in many physical functions in microvessel including protection of the vessel wall with harmful levels of fluid shear. Hence, understanding the impact of the glycocalyx layer is important to develop of human medicine for the treatment of cardiovascular disorders. By experiment it observed that the glycocalyx layer embraces negative charges in the electric-double layer which interacting with plasma phase (treated as an electrolyte) adjoin to the microvessel wall and induces various mechanical and electrochemical phenomena at the interfacial layer. A two fluid model is considered to define the nature of the blood flow. The electrochemical characteristics of the glycocalyx layer are defined by Gouy–Chapman theory. The Navier–Stokes equation related to the blood flow and Poisson equation related to the charge density are solve analytically and represent in the form of Bessel function and hyper-geometric function. The charge effect of glycocalyx layer on the blood flow due to permeability of the wall, conditions at the interface of the clear and peripheral region, boundary condition at the wall mainly slip or no-slip condition and the rheology of blood are discussed and displays through graphs. The behavior of the glycocalyx layer which plays a vital role in the cardiovascular disorders such as atherosclerosis, are discussed under the influence of different parameters. It will give more brief idea on the electrochemical nature and electrokinetic effect of the glycocalyx layer.

内皮糖萼整合的作用对于靶向静脉内纳米颗粒药物递送很重要。它在微血管的许多物理功能中起着至关重要的作用，包括用有害水平的流体剪切保护血管壁。因此，了解糖萼层的影响对于开发用于治疗心血管疾病的人类医学非常重要。通过实验，它观察到糖萼层在双电荷层中包含负电荷，该负电荷与血浆相（作为电解质）相互作用，并与微血管壁邻接，并在界面层引起各种机械和电化学现象。考虑使用两种流体模型来定义血流的性质。糖萼层的电化学特性由Gouy-Chapman理论定义。通过解析求解与血流有关的Navier–Stokes方程和与电荷密度有关的Poisson方程，并以Bessel函数和超几何函数的形式表示。讨论并显示了糖萼层由于壁的渗透性，透明区域和外围区域的界面条件，壁的边界条件（主要是滑移或不滑移条件）以及血液流变性引起的血流电荷效应。图。在不同参数的影响下，对在心血管疾病（如动脉粥样硬化）中起至关重要作用的糖萼层的行为进行了讨论。它将对糖萼层的电化学性质和电动效应提供更简短的想法。