Acridinium benzoates for ratiometric fluorescence imaging of cellular viscosity,Analyst

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Acridinium benzoates for ratiometric fluorescence imaging of cellular viscosity
Analyst ( IF 4.2 ) Pub Date : 2021-1-11 , DOI: 10.1039/d0an02321c
Min Wen _{1,

2,

3,

4,

5} , Chen Li _{1,

2,

3,

4,

5} , Mengyuan Zhang _{1,

2,

3,

4,

5} , Yan Sun _{1,

2,

3,

4,

5} , Fengming Liu _{6,

7,

8} , Xiaoyan Cui _{1,

2,

3,

4,

5} , Yongkui Shan _{1,

2,

3,

4,

5}

Affiliation

A series of fluorescent molecular rotors, acridinium benzoates (Acr-A,B,C,D), were designed for ratiometrically monitoring cellular viscosity. High sensitivity to viscosity was observed in probe Acr-A with an insignificant steric effect in the acridinium nitrogen. Acr-A was employed to distinguish cancer cells from normal cells and track the dynamics of viscosity during cellular apoptosis.

中文翻译：

苯甲酸cri啶鎓用于细胞粘度的比例荧光成像

设计了一系列荧光分子转子，cri啶a（Acr-A，B，C，D），用于按比例监测细胞粘度。在探针Acr-A中观察到对粘度的高敏感性，在in啶氮中的空间效应不明显。Acr-A用于区分癌细胞和正常细胞，并跟踪细胞凋亡过程中的黏度动态。

更新日期：2021-02-01

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