Vitiligo, an autoimmune disorder, is associated with altered cytokine levels and T lymphocytes. Lenalidomide modulates immune system components by altering cytokine production and regulating T-cell stimulation. In this study, effect of lenalidomide was checked on the development of vitiligo lesions, level of various cytokines, and T lymphocytes in the mouse model. The vitiligo mouse model was developed by immunizing C57BL/6 mouse with anti-mouse tyrosine-related protein 2. Lenalidomide was orally given to mice daily, and the effect was observed on the development of vitiligo lesions. The level of T lymphocytes in blood was checked by flow cytometry. Serum cytokine levels were checked by enzyme-linked immunosorbent assay. Vitiligo lesions were found significantly smaller in lenalidomide-treated mice models. It significantly decreased the serum levels of IFN-γ, TNF-α, IL-1β, and IL-6 but elevated the levels of IL-4 and IL-10. It non-significantly elevated CD4⁺/CD8⁺ T-cell ratio. Lenalidomide had an inhibitory effect on the development of vitiligo lesions in mice models by suppressing the serum level of pro-inflammatory cytokines and increasing anti-inflammatory cytokine levels. It modulated the immune response in vitiligo mice models toward an anti-inflammatory profile suggesting its use in the management of vitiligo.

中文翻译：

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来那度胺的免疫调节作用抑制白癜风小鼠模型中病变的进展

白癜风是一种自身免疫性疾病，与细胞因子水平和 T 淋巴细胞的改变有关。来那度胺通过改变细胞因子产生和调节 T 细胞刺激来调节免疫系统成分。在这项研究中，检查了来那度胺对小鼠模型中白癜风病变发展、各种细胞因子水平和 T 淋巴细胞的影响。用抗小鼠酪氨酸相关蛋白2免疫C57BL/6小鼠建立白斑小鼠模型。每天给小鼠口服来那度胺，观察对白斑病灶发展的影响。流式细胞仪检测血液中T淋巴细胞的水平。通过酶联免疫吸附测定检查血清细胞因子水平。在来那度胺治疗的小鼠模型中发现白癜风病变明显更小。它显着降低了 IFN-γ、TNF-α、IL-1β 和 IL-6 的血清水平，但提高了 IL-4 和 IL-10 的水平。它不显着升高CD4⁺ /CD8 ⁺ T 细胞比率。来那度胺通过抑制血清促炎细胞因子水平和增加抗炎细胞因子水平，对小鼠模型中白癜风病变的发展具有抑制作用。它调节白癜风小鼠模型中的免疫反应，使其具有抗炎特性，表明其可用于治疗白癜风。