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Simultaneous reconstruction of optical absorption property and speed of sound in intravascular photoacoustic tomography
Applied Mathematics in Science and Engineering ( IF 1.3 ) Pub Date : 2021-01-31 , DOI: 10.1080/17415977.2021.1879805
Zheng Sun 1 , Li-shuang Sun 1
Affiliation  

Intravascular photoacoustic tomography (IVPAT) is a newly developed imaging modality for the diagnosis and intervention of coronary artery diseases. It is an ill-posed nonlinear least squares (NLS) problem to recover the absorbed optical energy density (AOED) and optical absorption coefficient (OAC) distribution in the vascular cross sections from pressure photoacoustically generated by tissues with variable speed of sound (SoS). The prior knowledge of the SoS is usually unavailable before IVPAT scanning. The ideal assumption of a constant SoS leads to degraded image quality. This paper focuses on improvement of image quality for IVPAT in tissues with variable SoS by simultaneously recovering the SoS, AOED and OAC from the measured time-dependent pressure series. The joint recovery is implemented by alternately minimizing the errors between the measured and theoretical pressure by forward simulation. The demonstration results indicate that the normalized mean square absolute distance (NMSAD) of the reconstructions produced by this method is decreased by about 15% in comparison to that of the reconstructions with a fixed SoS. Comparison results show that this method outperforms the delay compensation method in recovering the AOED and the two-step algorithm in estimating the OAC by about 20% and 25% in NMSAD respectively.



中文翻译:

血管内光声层析成像中光吸收特性和声速的同时重建

血管内光声断层扫描(IVPAT)是一种新开发的用于诊断和干预冠状动脉疾病的成像方式。从具有可变声速 (SoS) 的组织光声产生的压力中恢复血管横截面中的吸收光能密度 (AOED) 和光吸收系数 (OAC) 分布是一个不适定的非线性最小二乘 (NLS) 问题. 在 IVPAT 扫描之前,通常无法获得 SoS 的先验知识。恒定 SoS 的理想假设会导致图像质量下降。本文侧重于通过从测量的时间相关压力序列中同时恢复 SoS、AOED 和 OAC,提高具有可变 SoS 的组织中 IVPAT 的图像质量。联合恢复是通过正向模拟交替最小化实测压力和理论压力之间的误差来实现的。演示结果表明,与具有固定 SoS 的重建相比,该方法产生的重建的归一化均方绝对距离 (NMSAD) 降低了约 15%。比较结果表明,该方法在恢复AOED方面比延迟补偿方法和在NMSAD中估计OAC方面的两步算法分别优于20%和25%。

更新日期:2021-01-31
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