Burkholderia gladioli is a bacterium with a broad ecology spanning disease in humans, animals and plants, but also encompassing multiple beneficial interactions. It is a plant pathogen, a toxin-producing food-poisoning agent, and causes lung infections in people with cystic fibrosis (CF). Contrasting beneficial traits include antifungal production exploited by insects to protect their eggs, plant protective abilities and antibiotic biosynthesis. We explored the genomic diversity and specialized metabolic potential of 206 B. gladioli strains, phylogenomically defining 5 clades. Historical disease pathovars (pv.) B. gladioli pv. allicola and B. gladioli pv. cocovenenans were distinct, while B. gladioli pv. gladioli and B. gladioli pv. agaricicola were indistinguishable; soft-rot disease and CF infection were conserved across all pathovars. Biosynthetic gene clusters (BGCs) for toxoflavin, caryoynencin and enacyloxin were dispersed across B. gladioli , but bongkrekic acid and gladiolin production were clade-specific. Strikingly, 13 % of CF infection strains characterized were bongkrekic acid-positive, uniquely linking this food-poisoning toxin to this aspect of B. gladioli disease. Mapping the population biology and metabolite production of B. gladioli has shed light on its diverse ecology, and by demonstrating that the antibiotic trimethoprim suppresses bongkrekic acid production, a potential therapeutic strategy to minimize poisoning risk in CF has been identified.

中文翻译：

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杀死和治愈：具有致病性和有益生活方式的剑兰伯克霍尔德菌的基因组系统发育和生物活性

剑兰伯克霍尔德菌 是一种具有广泛生态学的细菌，涵盖人类、动物和植物的疾病，但也包含多种有益的相互作用。它是一种植物病原体，一种产生毒素的食物中毒剂，会导致囊性纤维化 (CF) 患者的肺部感染。对比有益的特性包括昆虫利用抗真菌生产来保护它们的卵、植物保护能力和抗生素生物合成。我们探索了 206 个剑兰菌株的基因组多样性和专门的代谢潜力，在系统发育学上定义了 5 个进化枝。历史疾病pathovars（PV） B.唐菖蒲PV。allicola和B. 剑兰pv。椰聚糖 是不同的，而B. 剑兰pv。剑兰和B. 剑兰光伏。agaricicola难以区分；软腐病和 CF 感染在所有病原体中都是保守的。毒素黄素、caryoynencin 和 enacyloxin 的生物合成基因簇 (BGC) 分散在剑兰中，但 bongkrekic 酸和剑兰生产是进化枝特异性的。引人注目的是，13% 的 CF 感染菌株的特征是 bongkrekic 酸阳性，独特地将这种食物中毒毒素与剑兰病的这一方面联系起来。绘制剑兰的种群生物学和代谢物生产图 阐明了其多样化的生态，并通过证明抗生素甲氧苄氨嘧啶抑制 bongkrekic 酸的产生，确定了一种潜在的治疗策略，以最大限度地减少 CF 中毒风险。