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Insulin Resistance and Non-Alcoholic Fatty Liver Disease in Premenopausal Women with Metabolic Syndrome
Hormone and Metabolic Research ( IF 2.2 ) Pub Date : 2021-01-29 , DOI: 10.1055/a-1341-9710
Amr Ali El-Sehrawy 1 , Omnia State 1 , Rasha Rizk Elzehery 2 , Ahmed Salem Mohamed 1
Affiliation  

It is suggested that estrogen protects premenopausal women against non-alcoholic fatty liver disease. From another perspective, the relation between metabolic syndrome (MetS) and non-alcoholic fatty liver disease (NAFLD) is bidirectional. Role of insulin resistance (IR) in NAFLD continues to be a matter of debate. The present study aimed to assess the relation between IR and NAFLD in premenopausal women with MetS. The study included 51 premenopausal women with MetS. In addition, there were 40 age-matched healthy controls. All participants were subjected to careful history taking and thorough clinical examination. Performed laboratory investigations included fasting blood glucose, fasting insulin, lipid profile, and liver functions. Calculation of IR was achieved by the Homeostasis Model Assessment (HOMA-IR). NAFLD was graded into three grades according to findings of abdominal ultrasound. Patients had significantly higher BMI, SBP, DBP, FBG, fasting insulin, HOMA-IR, total cholesterol, triglycerides, and LDL levels when compared with controls. They also had significantly lower HDL levels in comparison to controls. Moreover, they have more advanced grades of NAFLD in contrast to controls. Comparison between patients with various grades of NAFLD regarding the clinical data revealed significant increase of fasting insulin and HOMA-IR levels with advancing NAFLD grade. Using multivariate regression analysis, HOMA-IR was an independent predictor of advanced NAFLD grade. In conclusion, the present study documented a combined inter-relation between MetS, IR, and NAFLD in premenopausal women with MetS. IR is correlated with NAFLD grade.

中文翻译:

代谢综合征绝经前妇女的胰岛素抵抗和非酒精性脂肪肝

建议雌激素保护绝经前妇女免受非酒精性脂肪肝疾病。从另一个角度来看,代谢综合征(MetS)和非酒精性脂肪肝(NAFLD)之间的关系是双向的。胰岛素抵抗 (IR) 在 NAFLD 中的作用仍然是一个有争议的问题。本研究旨在评估患有 MetS 的绝经前妇女的 IR 和 NAFLD 之间的关系。该研究包括 51 名患有 MetS 的绝经前妇女。此外,还有 40 名年龄匹配的健康对照。所有参与者都接受了仔细的病史采集和彻底的临床检查。进行的实验室调查包括空腹血糖、空腹胰岛素、血脂和肝功能。IR 的计算是通过稳态模型评估 (HOMA-IR) 实现的。根据腹部超声检查结果将NAFLD分为三个等级。与对照组相比,患者的 BMI、SBP、DBP、FBG、空腹胰岛素、HOMA-IR、总胆固醇、甘油三酯和 LDL 水平显着升高。与对照组相比,他们的 HDL 水平也显着降低。此外,与对照相比,它们具有更高级的 NAFLD。不同级别 NAFLD 患者之间临床数据的比较显示,随着 NAFLD 级别的提高,空腹胰岛素和 HOMA-IR 水平显着增加。使用多元回归分析,HOMA-IR 是晚期 NAFLD 分级的独立预测因子。总之,本研究记录了绝经前患有 MetS 的女性中 MetS、IR 和 NAFLD 之间的综合相互关系。IR 与 NAFLD 等级相关。
更新日期:2021-01-31
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