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Assessment of risk factors for postoperative cognitive dysfunction after coronary artery bypass surgery: a single-centre retrospective cohort study.
Bioscience Reports ( IF 4 ) Pub Date : 2021-01-29 , DOI: 10.1042/bsr20190719
Yongtao Sun 1 , Hai Feng 1 , Ting Zou 1 , Ming Hou 1 , Yanwu Jin 2 , Changping Gu 1 , Yuelan Wang 1 , Juan Li 3 , Mengjie Liu 1 , Min Zhang 1 , Yalei Gao 1
Affiliation  

To find out risk factors for postoperative cognitive dysfunction (POCD) after coronary artery bypass grafting (CABG), and to provide basis for clinically prevention of POCD. A total of 88 patients underwent CABG were surveyed with Telephone Questionnaire (TICS-M) for their cognitive impairment after 3, 7, 21, 90, 180d surgery. The occurrence of POCD was diagnosed by Neuropsychological Battery which including Vocabular Learning Test (VLT), Wisconsin Card Sorting Test (WCST), Trail Making Test (TMT) and Symbol Digit Modalities Test (SDMT). The preoperative, intraoperative and postoperative risk factors were assessed by the χ2 or t test. Multivariate analysis was used to study the correlation between the risk factors and the occurrence of POCD. Age, aortic plaque, carotid artery stenosis, cerebrovascular disease, anesthesia time, the rate of decline in intraoperative hemoglobin concentration (ΔHb) and systemic inflammatory response syndrome (SIRS) score on postoperative 2d have significant statistically (P < 0.05) influence on the occurrence of POCD. Aortic plaque, carotid artery stenosis, anesthesia time and SIRS score (OR value > 1, P < 0.05) are risk factors for POCD. The incidence of 21d and 180d POCD was approximately 26.1 % and 22.7 %, respectively.

中文翻译:

冠状动脉搭桥术后认知功能障碍的危险因素评估:一项单中心回顾性队列研究。

探讨冠状动脉旁路移植术(CABG)术后认知功能障碍(POCD)的危险因素,为临床预防POCD提供依据。88 名接受 CABG 的患者在手术 3、7、21、90、180 d 后接受了电话问卷(TICS-M)调查。POCD的发生由神经心理学电池诊断,包括词汇学习测试(VLT)、威斯康星卡片分类测试(WCST)、线索制作测试(TMT)和符号数字模态测试(SDMT)。通过χ2或t检验评估术前、术中和术后危险因素。多因素分析用于研究危险因素与POCD发生的相关性。年龄、主动脉斑块、颈动脉狭窄、脑血管疾病、麻醉时间、术后2d术中血红蛋白浓度(ΔHb)下降率和全身炎症反应综合征(SIRS)评分对POCD的发生有显着的统计学影响(P<0.05)。主动脉斑块、颈动脉狭窄、麻醉时间和SIRS评分(OR值>1,P<0.05)是POCD的危险因素。21 天和 180 天 POCD 的发生率分别约为 26.1% 和 22.7%。
更新日期:2021-02-01
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