ZnO nanoparticles embedded in zinc acetate matrix were synthesized by chemical route. The effect of thio-acetamide concentration during its synthesis was probed by structural, morphological, optical and bioactivity studies. XRD characterization indicated the formation of dominant phase of zinc acetate along with the low intensity peak of wurtzite ZnO. Morphological transition from bulky-like feature to flower-like feature via flake-like feature, is evidenced with increasing thio-acetamide molar concentrations. The optical band gap of samples decreased from ∼3.29 to 3.24 eV whereas the emitted color shifted from near green to blue region with increasing of molar concentration of thio-acetamide from 0 to 30% in the sample. The nanoparticles exhibited antimicrobial activity against seven (7) common human pathogenic bacteria including drug resistant varieties K. pneumonaie and S. aureus. The nanoparticles formed pores in the biological model membranes made from egg-phosphatidyl choline. Our study reveals that the thio-acetamide modified ZnO nanoparticles embedded in zinc acetate matrix could be used as potential drug lead to fight drug resistance against K. pneumoniae and S. aureus.

通过化学途径合成了包埋在醋酸锌基体中的ZnO纳米粒子。通过结构，形态，光学和生物活性研究探索了硫代乙酰胺浓度在合成过程中的影响。XRD表征表明乙酸锌主相的形成以及纤锌矿ZnO的低强度峰。硫代乙酰胺摩尔浓度的增加证明了从片状特征到片状特征通过片状特征的形态学转变。样品的光学带隙从约3.29 eV降低到3.24 eV，而随着样品中硫代乙酰胺的摩尔浓度从0增加到30％，发射的颜色从近绿色移到蓝色区域。ķ。肺炎和金黄色葡萄球菌。纳米颗粒在由卵磷脂酰胆碱制成的生物模型膜中形成孔。我们的研究表明，嵌入乙酸锌基质中的硫代-乙酰胺改性的ZnO纳米颗粒可作为潜在的药物抗K药。肺炎和金黄色葡萄球菌。