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Rapid microwave-assisted biosynthesis of chitooligosaccharide coated silver nanoparticles: assessments of antimicrobial activity for paediatric pulp therapy
Advances in Natural Sciences: Nanoscience and Nanotechnology Pub Date : 2021-01-29 , DOI: 10.1088/2043-6254/abc757
Subhathira Rajasekaran 1 , Sneha S Rao 2 , Pandurang Appana Dalavi 2 , Ashwini Prabhu 2 , Sukumaran Anil 3 , Jayachandran Venkatesan 2 , Sham S Bhat 1
Affiliation  

Silver nanoparticles (AgNPs) have gained much attention in the treatment of dental caries due to their excellent antimicrobial activities. In this study, we have biosynthesised chitooligosaccharide coated silver nanoparticles (COS-AgNPs) using a rapid microwave-assisted method. The physical and chemical characterisations of biosynthesised COS-AgNPs were investigated using UV–visible spectroscopy (UV–vis), dynamic light scattering (DLS), Fourier transform infrared spectroscopy (FTIR), X-Ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM) and transmission electron microscopy (TEM) equipped with selected area electron diffraction (SAED). Further, the developed COS-AgNPs were assessed for antimicrobial activity on Streptococcus mutans. From the DLS analysis, the average particle size of the COS-AgNPs was found to be ∼32 nm. The morphologies of the COS-AgNPs were monodisperse and spherical in shape. XRD peaks are coherent with the standard peaks of AgNPs. Antimicrobial activity of COS-AgNPs showed a significant zone of inhibition due to the synergistic effect of COS-AgNPs. Furthermore, the antibacterial potential of developed COS-AgNPs-Ca(OH)2 paste was checked against Streptococcus mutans, Staphylococcus aureus, and Enterococcus faecalis. COS-AgNPs based composite paste showed better inhibition zone against the tested microbes. Hence, COS-AgNPs and COS-AgNPs-Ca(OH)2 based paste materials will be promising biomaterials for pulp therapy in paediatric dentistry.



中文翻译:

微波辅助壳寡糖包覆的银纳米粒子的快速生物合成:儿童牙髓治疗的抗菌活性评估

银纳米颗粒(AgNPs)由于其优异的抗菌活性而在龋齿的治疗中引起了广泛的关注。在这项研究中,我们已经使用快速微波辅助方法生物合成了壳寡糖包被的银纳米颗粒(COS-AgNPs)。使用紫外可见光谱(UV-vis),动态光散射(DLS),傅里叶变换红外光谱(FTIR),X射线衍射(XRD),场发射扫描电子对生物合成的COS-AgNPs的物理和化学特征进行了研究。显微镜(FE-SEM)和透射电子显微镜(TEM)配备选定区域电子衍射(SAED)。此外,评估了已开发的COS-AgNPs对变形链球菌的抗菌活性。。通过DLS分析,发现COS-AgNP的平均粒径为〜32nm。COS-AgNPs的形态为单分散和球形。XRD峰与AgNPs的标准峰相干。COS-AgNPs的抗菌活性由于COS-AgNPs的协同作用而显示出明显的抑制作用。此外,检查了已开发的COS-AgNPs-Ca(OH)2糊剂对变形链球菌金黄色葡萄球菌粪肠球菌的抗菌潜力。基于COS-AgNPs的复合糊剂对被测微生物表现出更好的抑制区。因此,COS-AgNPs和COS-AgNPs-Ca(OH)2 基糊状材料将成为用于儿科牙髓治疗的有前途的生物材料。

更新日期:2021-01-29
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