Development of novel metallodrugs with pharmacological profile plays a significant role in modern medicinal chemistry and drug design. Metal complexes have shown remarkable clinical results in current cancer therapy. Gold complexes have attained attention due to their high antiproliferative potential. Gold-based drugs are used for the treatment of rheumatoid arthritis. Gold-containing compounds with selective and specific targets are capable to assuage the symptoms of a range of human diseases. Gold (I) species with labile ligands (such as Cl in TEPAuCl) interact with isolated DNA; therefore, this biomolecule has been considered as a target for gold drugs. Gold (I) has a high affinity towards sulfur and selenium. Due to this, gold (I) drugs readily interact with cysteine or selenocysteine residue of the enzyme to form protein-gold(I) thiolate or protein-gold (I) selenolate complexes that lead to inhibition of the enzyme activity. Au(III) compounds due to their square-planner geometriesthe same as found in cisplatin, represent a good source for the development of anti-tumor agents. This article aims to review the most important applications of gold products in the treatment of human colon cancer and to analyze the complex interplay between gold and the human body.

具有药理学特征的新型金属药物的开发在现代药物化学和药物设计中起着重要作用。金属配合物在当前的癌症治疗中已显示出显着的临床结果。金配合物由于其高增殖潜力而受到关注。金基药物用于治疗类风湿关节炎。具有选择性和特异性靶标的含金化合物能够缓解一系列人类疾病的症状。具有不稳定配体的金（I）物种（例如TEPAuCl中的Cl）与分离的DNA相互作用；因此，该生物分子被认为是金药的靶标。金（I）对硫和硒具有高亲和力。由于此，金（I）药物很容易与酶的半胱氨酸或硒代半胱氨酸残基相互作用，形成蛋白质-金（I）硫醇盐或蛋白质-金（I）硒酸盐复合物，从而抑制酶的活性。由于Au（III）化合物的方形结构与顺铂相同，因此是开发抗肿瘤药物的良好来源。本文旨在综述金产品在人类结肠癌治疗中的最重要应用，并分析金与人体之间的复杂相互作用。