Advanced Parkinson’s disease (PD) often brings a set of motor and non-motor features that are particularly challenging to manage. Medication options can be limited by side-effects and quality of life can be severely affected by an accumulating burden of nonmotor symptoms. Here, we reviewed the literature and our clinical experience with the aim of providing a practical approach to the management of advanced PD. We provide guidelines for treatment of physical and neurobehavioral concerns, that occur in advanced PD.

中文翻译：

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晚期帕金森病的治疗

晚期帕金森病 (PD) 通常会带来一组运动和非运动特征，这些特征特别难以管理。药物选择可能会受到副作用的限制，并且生活质量可能会因非运动症状的累积负担而受到严重影响。在这里，我们回顾了文献和我们的临床经验，旨在为晚期 PD 的管理提供一种实用的方法。我们提供治疗晚期 PD 中出现的身体和神经行为问题的指南。