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New twists in actin–microtubule interactions
Molecular Biology of the Cell ( IF 3.3 ) Pub Date : 2021-01-28 , DOI: 10.1091/mbc.e19-09-0491
Morgan L Pimm 1 , Jessica L Henty-Ridilla 1, 2
Affiliation  

Actin filaments and microtubules are cytoskeletal polymers that participate in many vital cell functions including division, morphogenesis, phagocytosis, and motility. Despite the persistent dogma that actin filament and microtubule networks are distinct in localization, structure, and function, a growing body of evidence shows that these elements are choreographed through intricate mechanisms sensitive to either polymer. Many proteins and cellular signals that mediate actin–microtubule interactions have already been identified. However, the impact of these regulators is typically assessed with actin filament or microtubule polymers alone, independent of the other system. Further, unconventional modes and regulators coordinating actin–microtubule interactions are still being discovered. Here we examine several methods of actin–microtubule crosstalk with an emphasis on the molecular links between both polymer systems and their higher-order interactions.



中文翻译:

肌动蛋白-微管相互作用的新变化

肌动蛋白丝和微管是细胞骨架聚合物,参与许多重要的细胞功能,包括分裂、形态发生、吞噬作用和运动。尽管肌动蛋白丝和微管网络在定位、结构和功能上是不同的,但越来越多的证据表明,这些元素是通过对任一聚合物敏感的复杂机制进行编排的。许多介导肌动蛋白-微管相互作用的蛋白质和细胞信号已经被鉴定出来。然而,这些调节器的影响通常单独使用肌动蛋白丝或微管聚合物进行评估,独立于其他系统。此外,仍在发现协调肌动蛋白-微管相互作用的非常规模式和调节剂。

更新日期:2021-01-29
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