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Stromal cell‐derived factor‐1/Exendin‐4 cotherapy facilitates the proliferation, migration and osteogenic differentiation of human periodontal ligament stem cells in vitro and promotes periodontal bone regeneration in vivo
Cell Proliferation ( IF 8.5 ) Pub Date : 2021-01-29 , DOI: 10.1111/cpr.12997 Qianyu Liang 1 , Lingqian Du 2 , Rui Zhang 1, 3 , Wenyan Kang 1 , Shaohua Ge 1
Cell Proliferation ( IF 8.5 ) Pub Date : 2021-01-29 , DOI: 10.1111/cpr.12997 Qianyu Liang 1 , Lingqian Du 2 , Rui Zhang 1, 3 , Wenyan Kang 1 , Shaohua Ge 1
Affiliation
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Stromal cell‐derived factor‐1 (SDF‐1) actively directs endogenous cell homing. Exendin‐4 (EX‐4) promotes stem cell osteogenic differentiation. Studies revealed that EX‐4 strengthened SDF‐1‐mediated stem cell migration. However, the effects of SDF‐1 and EX‐4 on periodontal ligament stem cells (PDLSCs) and bone regeneration have not been investigated. In this study, we aimed to evaluate the effects of SDF‐1/EX‐4 cotherapy on PDLSCs in vitro and periodontal bone regeneration in vivo.
中文翻译：
基质细胞衍生因子-1 / Exendin-4联合疗法促进体外人牙周膜干细胞的增殖，迁移和成骨分化，并促进体内牙周骨再生
基质细胞衍生因子-1（SDF-1）主动指导内源性细胞归巢。Exendin-4（EX-4）促进干细胞成骨分化。研究表明，EX-4增强了SDF-1介导的干细胞迁移。但是，尚未研究SDF-1和EX-4对牙周膜干细胞（PDLSC）和骨再生的影响。在这项研究中，我们旨在评估SDF-1 / EX-4联合疗法对体外PDLSCs和体内牙周骨再生的影响。
更新日期：2021-03-09
中文翻译：
基质细胞衍生因子-1 / Exendin-4联合疗法促进体外人牙周膜干细胞的增殖，迁移和成骨分化，并促进体内牙周骨再生
基质细胞衍生因子-1（SDF-1）主动指导内源性细胞归巢。Exendin-4（EX-4）促进干细胞成骨分化。研究表明，EX-4增强了SDF-1介导的干细胞迁移。但是，尚未研究SDF-1和EX-4对牙周膜干细胞（PDLSC）和骨再生的影响。在这项研究中，我们旨在评估SDF-1 / EX-4联合疗法对体外PDLSCs和体内牙周骨再生的影响。
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