The microbiome is a rapidly advancing biomedical frontier with relevance for psychiatric illness. The gut microbiota interact with the central nervous system bidirectionally through the gut–brain axis and generate substances that may influence host metabolism, including short-chain fatty acids such as butyrate. Understanding gut microbiota in bipolar disorder (BD) may suggest new disease markers and treatment approaches.

中文翻译：

---

双相情感障碍和肠道微生物组：系统评价

微生物组是与精神疾病相关的快速发展的生物医学前沿。肠道微生物群通过肠-脑轴与中枢神经系统双向相互作用，并产生可能影响宿主代谢的物质，包括丁酸等短链脂肪酸。了解双相情感障碍 (BD) 中的肠道微生物群可能会提示新的疾病标志物和治疗方法。