The history of protistology and the introduction of modern methods of unicell observations is described in a large maritime laboratory over a period of forty years by the initiator of this new team. The development of this team and the doctoral theses developed there are described as well as the major discoveries made. The Arago Laboratory, which was then in 1960 a field laboratory mainly devoted to the collection of biological material, becomes a research laboratory specializing in the study of the major fundamental problems which govern life: the organization and expression of the genome, mitotic processes and their nuclear and cytoplasmic components, cell cycle and its regulation as well as molecular phylogeny. The biological models chosen were essentially the dinoflagellate protists in their great variety: autotrophs, heterotrophs, myxotrophs and able of proliferating at sea, thus disrupting their cell cycle. Coupled with the techniques of biochemistry and molecular biology which it was in its infancy, the most advanced observation methods used electron and confocal microscopy often after use of ultra-cold cryopreparations, necessary to preserve the antigenic sites and allow the highlighting new proteins. The dinoflagellate model was then abandoned in favor of unicellular micro-eukaryotes allowing the development of environmental genomics.

这个新团队的发起者在一个大型海事实验室长达40年的时间里，描述了分子生物学的历史和现代单细胞观察方法的介绍。描述了该团队的发展以及在那里开发的博士学位论文以及取得的主要发现。Arago实验室（当时是1960年的现场实验室，主要致力于生物材料的收集）成为了研究实验室，专门研究控制生命的主要基本问题：基因组的组织和表达，有丝分裂过程及其核和细胞质成分，细胞周期及其调控以及分子系统发育。选择的生物学模型本质上是种类繁多的鞭毛藻生物：自养生物，异养生物，粘菌和能够在海上增殖，从而破坏其细胞周期。结合处于起步阶段的生物化学和分子生物学技术，最先进的观察方法通常是在使用超冷冷冻后使用电子显微镜和共聚焦显微镜，这对于保留抗原位点并允许突出显示新蛋白质是必不可少的。然后放弃了鞭毛藻模型，取而代之的是单细胞微型真核生物，从而发展了环境基因组学。保留抗原位点并允许突出显示新蛋白所必需。然后放弃了鞭毛藻模型，取而代之的是单细胞微型真核生物，从而发展了环境基因组学。保留抗原位点并允许突出显示新蛋白所必需。然后放弃了鞭毛藻模型，取而代之的是单细胞微型真核生物，从而发展了环境基因组学。