The environmental contamination with lead (Pb) is considered a critical issue worldwide. Therefore, this study aimed to evaluate the expression levels of circulating miRNAs (miR-155, miR-126, and miR-145) in Mexican women exposed to Pb. Blood lead levels (BLL) were assessed in enrolled women (n = 190) using an atomic absorption method. Also, serum miRNAs expression levels were quantified through a real-time PCR assay. A mean BLL of 10.5 ± 4.50 μg/dL was detected. Overexpression of miR-155 was detected in highly exposed women. Besides, a significant simple positive relationship (p < 0.05) was found between BLL and serum miR-155 expression levels. Additionally, a significant inverse correlation (p < 0.05) was determined between BLL and serum miR-126 expression levels, as downregulation of miR-126 expression levels was observed in highly exposed women. The findings in this study are the concern, as epigenetic changes detected may represent a connection between health illnesses and Pb exposure.

铅（Pb）对环境的污染被认为是世界范围内的关键问题。因此，本研究旨在评估暴露于Pb的墨西哥妇女中循环miRNA（miR-155，miR-126和miR-145）的表达水平。使用原子吸收法评估入组女性（n = 190）的血铅水平（BLL）。另外，通过实时PCR测定法定量了血清miRNA的表达水平。检测到的平均BLL为10.5±4.50μg/ dL。在高度暴露的女性中检测到miR-155的过度表达。此外，在BLL和血清miR-155表达水平之间发现显着的简单正相关（p <0.05）。此外，BLL与血清miR-126表达水平之间存在显着的负相关（p <0.05），因为在高度接触的女性中观察到miR-126表达水平的下调。这项研究的结果令人担忧，因为检测到的表观遗传变化可能代表健康疾病与铅暴露之间的联系。