当前位置: X-MOL 学术Curr. Probl. Cancer › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Urachal carcinoma: A case of a rare neoplasm
Current Problems in Cancer ( IF 2.6 ) Pub Date : 2021-01-28 , DOI: 10.1016/j.currproblcancer.2021.100711
Inês Moreira 1 , Sara Coelho 1 , Ângelo Rodrigues 2 , Ana Sofia Patrão 1 , Maria Joaquina Maurício 1
Affiliation  

Introduction: Urachal carcinoma is a rare type of non-urothelial malignancy that arises from the urachal ligament, a remnant of fetal development. It frequently involves the dome of the bladder or its midline, with adenocarcinoma being the most common histological type. This malignancy is generally diagnosed in advanced stages and is associated with poor prognosis. Case report: A 40-year-old woman was referred to hospital due to recurrent urinary tract infections. Imaging studies showed the presence of a 3.7 cm tumor in the bladder dome that extended to the posterior region of the umbilicus. A biopsy through cystoscopy confirmed the diagnosis of urachal carcinoma. Since there were no metastases, the patient underwent partial cystectomy and resection of the urachal ligament and the umbilicus. Surgical margins were negative and it was considered a complete resection. Nine months later, disease progression occurred, with peritoneal carcinomatosis, multiple adenopathies and a 4 cm mass in the pelvic cavity with invasion of the vagina, rectum, and sigmoid colon. She began palliative chemotherapy with cisplatine and 5-fluorouracil. After 7 cycles, progression was again observed, with an increase of the pelvic mass, vaginal and rectal hemorrhage, multiple intramuscular implants, bilateral axillary adenopathies, as well as lesion in the right breast, which was compatible with metastasis from urachal carcinoma. She underwent hemostatic radiotherapy to the pelvic mass and second line palliative chemotherapy with gemcitabine and paclitaxel. After 4 cycles, the patient clinically deteriorated and eventually died. Conclusion: Urachal carcinoma is an aggressive malignancy. Although systemic treatment may be effective in disease control, a standard chemotherapy regimen is yet to be determined. Multicenter trials are needed to clarify the best treatment approach in these patients.



中文翻译:

脐尿管癌:一例罕见肿瘤

简介:脐尿管癌是一种罕见的非尿路上皮恶性肿瘤,起源于脐尿管韧带,是胎儿发育的残余物。它经常涉及膀胱穹顶或其中线,腺癌是最常见的组织学类型。这种恶性肿瘤通常在晚期被诊断出来,并且与预后不良有关。案例报告:一名 40 岁女性因反复尿路感染被转诊至医院。影像学研究显示,膀胱穹窿中存在一个 3.7 cm 的肿瘤,并延伸至脐后部。膀胱镜活检证实脐尿管癌的诊断。由于没有转移,患者接受了部分膀胱切除术和脐尿管韧带和脐部切除术。手术切缘为阴性,被认为是完全切除。9 个月后,疾病进展,出现腹膜癌病、多发性腺病和盆腔内 4 厘米的肿块,侵犯阴道、直肠和乙状结肠。她开始使用顺铂和 5-氟尿嘧啶进行姑息性化疗。7个周期后,再次观察到进展,盆腔肿块增加,阴道和直肠出血、多处肌内植入物、双侧腋窝淋巴结肿大以及右乳病变,与脐尿管癌转移相符。她接受了盆腔肿块的止血放疗和吉西他滨和紫杉醇的二线姑息化疗。4个周期后,患者临床恶化,最终死亡。结论:脐尿管癌是一种侵袭性恶性肿瘤。尽管全身治疗可能对疾病控制有效,但标准化疗方案尚未确定。需要多中心试验来阐明这些患者的最佳治疗方法。

更新日期:2021-01-28
down
wechat
bug