A novel coordination polymer based on Co(II) was synthesized by reacting Co(NO₃)₂·6H₂O with H₂DCTP in the existence of a second nitrogen-donor L ligand through a mixed-ligand approach. Its chemical formula is [Co₂(OH)(L)(DCTP)_1.5]_n (1, H₂DCTP = 2,5-dichloroterephthalic acid and L = 1,3-bis[5,6-methylbenzimidazol-1-yl]propane). Biological experiments were conducted for the evaluation of the compound’s protective effect on brain injury after subarachnoid hemorrhage. Neuron-specific enolase and adrenomedullin contents were determined. Furthermore, the expression levels of tumor necrosis factor receptor-associated factor 6 in the brain tissue were measured by Western blot after treatment with the compound. Molecular docking study indicated that the carboxyl groups on the p-dichlorobenzene were the main active groups that reacted with the target protein, whereas nitrogenous groups were the supportive groups for the entire metal complex.

通过混合配体方法，在第二个氮供体L配体存在下，使Co（NO ₃）₂ ·6H ₂ O与H ₂ DCTP反应，合成了一种新型的基于Co（II）的配位聚合物。其化学式为[Co ₂（OH）（L）（DCTP）_1.5 ] _n（1，H ₂DCTP ＝ 2，5-二氯对苯二甲酸，L ＝ 1，3-双[5，6-甲基苯并咪唑-1-基]丙烷。进行了生物学实验以评估该化合物对蛛网膜下腔出血后脑损伤的保护作用。测定神经元特异性烯醇化酶和肾上腺髓质素的含量。此外，用化合物处理后，通过蛋白质印迹法测量脑组织中肿瘤坏死因子受体相关因子6的表达水平。分子对接研究表明，对二氯苯上的羧基是与目标蛋白反应的主要活性基团，而含氮基团是整个金属配合物的支持基团。