In the current study, via using a mixed-ligand approach, a new Zn(II)-containing metal–organic structure (MOF), whose chemical formula is [[Zn₃(μ₃-cpboda)₂(1,4-bib)₅(H₂O)₂]·DMF]_n (1, H₃cpboda = 3,3′-((5-carboxy-1,3-phenylene)bis(oxy))dibenzoic acid, 1,4-bib = 1,4-di(1H-imidazol-1-yl)benzene)), has formed in the present of solvothermal environment and determined by single-crystal X-ray and elemental analysis (EA). Fluorescence measurements prove that complex 1 shows quick, hypersensitive, and high-selective luminescence quenching responses to 2,4,6-trinitrophenol (TNP) under aqueous solution condition. The treatment activity of the compound combined with ginsenoside on sepsis mice was measured and the related principle was detected in the meantime. The molecular docking simulation shows that both the carboxyl and five-membered ring containing nitrogen groups have the activities to the protein, which could explain the experimental observations.

在目前的研究中，通过使用混合配体方法中，新的Zn（II）的金属-有机结构（MOF），其化学式为[[锌₃（μ ₃ -cpboda）₂（1,4-围兜）₅（H ₂ O）₂ ]·DMF] _n（1，H ₃ cpboda = 3,3'-（（5-羧基-1,3-亚苯基）双（氧基））二苯甲酸，1,4-bib ＝ 1，4-二（1H-咪唑-1-基）苯）在溶剂热环境中形成并通过单晶X射线和元素分析（EA）确定。荧光测量证明络合物1在水溶液条件下显示出对2,4,6-三硝基苯酚（TNP）的快速，高度敏感和高选择性的发光淬灭响应。测定了该化合物与人参皂苷联合对败血症小鼠的治疗活性，并检测了相关原理。分子对接模拟表明，含氮的羧基和五元环均具有对蛋白质的活性，这可以解释实验结果。