A proficient and feasible approach towards polysubstituted quinolone conjugated 4H-pyrans has been elucidated. The illustrated phenomenon concern with the base-mediated multicomponent reaction and subsequent copper-catalyzed hydroxylation of C-X bond emerging in an amide functionality. The developed reaction conditions showcased considerable substrate scope and functional group tolerance by giving the desired products in good yields.

中文翻译：

---

多取代4的有效方法

已经阐明了对多取代的喹诺酮共轭的4 H-吡喃酮的一种熟练可行的方法。所示现象与碱介导的多组分反应以及随后在酰胺官能团中出现的铜催化的CX键的羟基化有关。通过提供高收率的所需产物，发达的反应条件显示出相当大的底物范围和官能团耐受性。