Ischemia-reperfusion injury (IRI) is an important factor limiting the success of cardiac reperfusion therapy. Curcumin has a significant cardioprotective effect against IRI, can inhibit ventricular remodeling induced by pressure load or MI, and improve cardiac function. However, the poor water solubility and low bioavailability of curcumin restrict its clinical application. In this study, we prepared and evaluated a curcumin-hydrogel (cur-hydrogel) to reduce cardiomyocyte apoptosis and reactive oxygen species formation induced by hypoxia-reoxygenation injury, promote autophagy, and reduce mitochondrial damage by maintaining the phosphorylation of Cx43. Meanwhile, cur-hydrogel can restore cardiac function, inhibit myocardial collagen deposition and apoptosis, and activate JAK2/STAT3 pathway to alleviate myocardial ischemia-reperfusion injury in rats. The purpose of this study is to elucidate the protective effects of cur-hydrogel on myocardial ischemia-reperfusion injury by regulating apoptosis, autophagy, and mitochondrial injury in vitro and in vivo, which lays a new theoretical and experimental foundation for the prevention and reduction of IRI.

中文翻译：

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姜黄素肽水凝胶通过上调自噬和保护线粒体功能减轻心肌缺血再灌注损伤

缺血再灌注损伤（IRI）是限制心脏再灌注治疗成功的重要因素。姜黄素对 IRI 有显着的心脏保护作用，能抑制压力负荷或 MI 引起的心室重构，改善心功能。但姜黄素水溶性差、生物利用度低等限制了其临床应用。在本研究中，我们制备并评估了一种姜黄素水凝胶（cur-hydrogel），通过维持 Cx43 的磷酸化来减少缺氧复氧损伤诱导的心肌细胞凋亡和活性氧形成，促进自噬，减少线粒体损伤。同时，cur-hydrogel可以恢复心脏功能，抑制心肌胶原沉积和细胞凋亡，并激活JAK2/STAT3通路减轻大鼠心肌缺血再灌注损伤。本研究旨在阐明cur-hydrogel在体外和体内通过调节细胞凋亡、自噬和线粒体损伤对心肌缺血再灌注损伤的保护作用，为预防和减轻心肌缺血再灌注损伤奠定新的理论和实验基础。 IRI。