Collaboration between industry and academia necessitates the management of entrepreneurial dynamics within ecosystem contexts. However, such partnerships perpetuate numerous challenges that, without effective management, can impact upon the ecosystem as a whole. Limited research to date has addressed the challenges affecting these university-industry partnerships and ascertained their impact upon ecosystem management. This study identifies the challenges pervading university-industry partnerships across entrepreneurial ecosystems, with a view that through an exposition of such challenges, more specific strategies could be implemented to address them. Questionnaires were distributed to key ecosystem stakeholders, requesting their perceptions of the key challenges affecting their collaborative relationships. Empirical data was analysed utilising fuzzy-set qualitative comparative analysis to deduce the configurational nature of the conditions. Results reveal mutually exclusive solutions grounded upon distinct combinations of conditions, constituting distinct pathways to ineffective ecosystem management. Theoretical and practical implications are discussed, as well as acknowledged limitations of this study and suggestions for future research.

工业界和学术界之间的合作需要在生态系统环境下管理企业家动力。但是，这种伙伴关系使许多挑战长期存在，如果没有有效的管理，这些挑战可能会影响整个生态系统。迄今为止，有限的研究已经解决了影响这些大学与行业伙伴关系的挑战，并确定了它们对生态系统管理的影响。这项研究确定了跨企业家生态系统的大学与行业伙伴关系所面临的挑战，并认为通过阐述这些挑战，可以实施更具体的策略来应对这些挑战。问卷被分发给生态系统的主要利益相关者，要求他们对影响他们的合作关系的主要挑战有所了解。利用模糊集定性比较分析对经验数据进行分析，以推断条件的配置性质。结果表明，互斥的解决方案基于不同的条件组合，构成了无效生态系统管理的不同途径。讨论了理论和实践意义，以及本研究的公认局限性和对未来研究的建议。