Spinal cord injury (SCI) always leads to functional deterioration due to a series of processes including cell death. In recent years, programmed cell death (PCD) is considered to be a critical process after SCI, and various forms of PCD were discovered in recent years, including apoptosis, necroptosis, autophagy, ferroptosis, pyroptosis and paraptosis. Unlike necrosis, PCD is known as an active cell death mediated by a cascade of gene expression events, and it is crucial for elimination unnecessary and damaged cells, as well as a defence mechanism. Therefore, it would be meaningful to characterize the roles of PCD to not only enhance our understanding of the pathophysiological processes, but also improve functional recovery after SCI. This review will summarize and explore the most recent advances on how apoptosis, necroptosis, autophagy, ferroptosis, pyroptosis and paraptosis are involved in SCI. This review can help us to understand the various functions of PCD in the pathological processes of SCI, and contribute to our novel understanding of SCI of unknown aetiology in the near future.

中文翻译：

---

程序性细胞死亡在脊髓损伤的发病机理和治疗中

脊髓损伤（SCI）总是会由于包括细胞死亡在内的一系列过程而导致功能恶化。近年来，程序性细胞死亡（PCD）被认为是SCI之后的关键过程，并且近年来发现了各种形式的PCD，包括细胞凋亡，坏死病，自噬，铁生性病，烧伤和副伤寒。与坏死不同，PCD被称为由一系列基因表达事件介导的活动性细胞死亡，对于消除不必要和受损的细胞以及防御机制至关重要。因此，表征PCD的作用不仅对加深我们对病理生理过程的了解，而且还可以改善SCI后的功能恢复，将是有意义的。这篇评论将总结并探索有关细胞凋亡，坏死病，自噬，SCI涉及铁素体病，发烧和截瘫。这篇综述可以帮助我们了解PCD在SCI病理过程中的各种功能，并有助于我们在不久的将来对未知病因的SCI有了新的认识。