Abstract

The study outcomes of dynamic parameters for the pro- and anitoxidant status and the cytokine profile in piglets under the stress caused by weaning them from sows for their transfer to growing-fattening facilities under conditions of an industrial-sized pig farm are reported. It has been ascertained that the technological stress affecting the animals is followed by increasing the contents of malondialdehyde and medium molecular-weight peptides, the endogenous intoxication, and the level of proinflammatory cytokines on days 3–10 after the stress effect. Increasing the antioxidant-defense enzyme activity and the levels of stable nitric-oxide metabolites and IL-4 and IL-10 anti-inflammatory cytokines contributed to normalizing the body’s metabolic processes and decreasing the contents of IL-1β, TNF-α, and IFN-γ anti-inflammatory cytokines. The dynamics of variations in the pro- and anitoxidant status and the cytokine profile can indicate their interdependence under the oxidative stress associated with the events of weaning and transferring them to growing-fattening facilities. The process of adaptation to the new conditions was usually completed on the 20th day after the stress effect. In addition, most analyzed parameters were restored to the preweaning levels.

中文翻译：

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技术应激条件下仔猪前，抗氧化状态与细胞因子谱的关系

摘要

据报道，在工业规模的养猪场条件下，仔猪断奶后转移到生长肥育场的压力下，仔猪中抗氧化剂和抗氧化剂状态以及细胞因子谱的动态参数的研究成果已经报道。可以确定的是，在影响动物的技术压力之后，会在压力作用后第3-10天增加丙二醛和中等分子量肽的含量，内源性中毒以及促炎细胞因子的水平。增加抗氧化防御酶的活性以及稳定的一氧化氮代谢产物和IL-4和IL-10抗炎细胞因子的水平有助于正常化人体的代谢过程并降低IL-1β，TNF-α和IFN的含量-γ抗炎细胞因子。抗氧化剂和抗氧化剂状态以及细胞因子谱的变化动态可以表明它们在与断奶和转移到生肥设施有关的氧化应激下相互依存。适应新条件的过程通常在压力影响后的第20天完成。此外，大多数分析参数已恢复到断奶前水平。