Objective To determine whether improvements in school age outcomes had occurred between two cohorts of births at 22–25 weeks of gestation to women residents in England in 1995 and 2006. Design Longitudinal national cohort studies. Setting School-based or home-based assessments at 11 years of age. Participants EPICure2 cohort of births at 22–26 weeks of gestation in England during 2006: a sample of 200 of 1031 survivors were evaluated; outcomes for 112 children born at 22–25 weeks of gestation were compared with those of 176 born in England during 1995 from the EPICure cohort. Classroom controls for each group acted as a reference population. Main outcome measures Standardised measures of cognition and academic attainment were combined with parent report of other impairments to estimate overall neurodevelopmental status. Results At 11 years in EPICure2, 18% had severe and 20% moderate impairments. Comparing births at 22–25 weeks in EPICure2 (n=112), 26% had severe and 21% moderate impairment compared with 18% and 32%, respectively, in EPICure. After adjustment, the OR of moderate or severe neurodevelopmental impairment in 2006 compared with 1995 was 0.76 (95% CI 0.45 to 1.31, p=0.32). IQ scores were similar in 1995 (mean 82.7, SD 18.4) and 2006 (81.4, SD 19.2), adjusted difference in mean z-scores 0.2 SD (95% CI −0.2 to 0.6), as were attainment test scores. The use of multiple imputation did not alter these findings. Conclusion Improvements in care and survival between 1995 and 2006 are not paralleled by improved cognitive or educational outcomes or a reduced rate of neurodevelopmental impairment. Data are available upon reasonable request. Data are available subject to the EPICure Data Sharing Policy () and will be available as part of the RECAP preterm Cohort Platform ().

中文翻译：

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极早产后 11 年神经发育没有变化

目的 确定 1995 年和 2006 年英格兰女性居民在妊娠 22-25 周时出生的两个队列之间的学龄结局是否有所改善。设计纵向全国队列研究。在 11 岁时设置基于学校或基于家庭的评估。参与者 EPICure2 2006 年英国妊娠 22-26 周出生队列：评估了 1031 名幸存者中的 200 名样本；将 112 名妊娠 22-25 周出生的儿童的结局与 EPICure 队列中 1995 年出生于英格兰的 176 名儿童的结局进行了比较。每个组的课堂控制作为参考人群。主要结果测量 将认知和学业成绩的标准化测量与其他损伤的家长报告相结合，以估计整体神经发育状态。结果 在 EPICure2 的 11 年中，18% 有严重损伤，20% 有中度损伤。比较 EPICure2 中 22-25 周的分娩（n=112），26% 有重度和 21% 中度损伤，而在 EPICure 中分别为 18% 和 32%。调整后，2006 年中重度神经发育障碍的 OR 与 1995 年相比为 0.76（95% CI 0.45 至 1.31，p=0.32）。IQ 分数在 1995 年（平均 82.7，SD 18.4）和 2006 年（81.4，SD 19.2）相似，调整后的平均 z 分数差异为 0.2 SD（95% CI -0.2 至 0.6），成绩测试分数也是如此。使用多重插补并没有改变这些发现。结论 1995 年至 2006 年间护理和生存的改善与认知或教育结果的改善或神经发育障碍率的降低并不平行。可应合理要求提供数据。) 并将作为 RECAP 早产队列平台的一部分提供 (）。