A recent upgrade of the time domain multi-wavelength optical mammograph developed by Politecnico di Milano achieved good performance in laboratory tests [Biomed. Opt. Express 9, 755 (2018). [CrossRef] ]. However, it proved unsatisfactory when in vivo measurements were finally performed. That led to a further upgrade, including the replacement of the time-to-digital converter with a new model, and the related set-up changes. The new instrument version offers improved laboratory performance (as assessed through established protocols: BIP and MEDPHOT) and good in vivo performance (extension of the scanned breast area, repeatability, consistency of estimated tissue composition with physiology). Besides introducing the new set-up and detailing its laboratory and in vivo performance, we highlight the importance of systematic in vivo testing before entering clinical trials.

中文翻译：

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体内测试驱动的时域多波长乳腺X线摄影机升级

Politecnico di Milano开发的时域多波长光学乳房X线摄影机的最新升级在实验室测试中取得了良好的性能[Biomed。选择。快递9，755（2018）。[CrossRef] ]。然而，当最终进行体内测量时，证明不令人满意。这导致了进一步的升级，包括用新型号替换了时间数字转换器以及相关的设置更改。新的仪器版本提供了改进的实验室性能（通过既定方案评估：BIP和MEDPHOT），并且体内性能良好性能（扫描的乳房区域的延伸，可重复性，估计的组织组成与生理的一致性）。除了介绍新设置并详细说明其实验室和体内性能外，我们还强调了进入临床试验之前进行系统体内测试的重要性。