Objective: Precision medicine raises hope for translating genetic-based knowledge about psychiatric risks into mental health benefits by motivating health-related, risk-reducing behaviors. Teenagers (ages 14–17) are an important age-group to engage in preventive efforts but, their views about psychiatric genetics are understudied. Method: An online survey with a nationally representative sample of teenagers (n = 417) was conducted. Participants were randomly assigned to receive 1 of 2 handouts, 1 emphasizing the genetic underpinnings of psychiatric conditions; the other agency-oriented and focusing on gene-environment interactions. Survey questions queried their views about behavioral changes in response to psychiatric genetic risk information and expressed willingness to undertake them. Participants’ decision-making characteristics (i.e., self-efficacy, empowerment, intolerance of uncertainty, and sensation-seeking) were assessed at baseline. Results: Teenagers strongly valued the information provided and its potential usefulness for their mental health. Information about psychiatric genetics alone impacted views about the causes of mental illness. Contrary to our hypothesis, the type of handout did not impact participants’ expressed willingness to make behavioral changes to reduce their risk of developing a psychiatric condition, but their sense of empowerment played a key role in their responses. Conclusion: Educating teenagers about gene-environment interactions may help facilitate the translational efforts of precision psychiatry. Research with teenagers across racial/ethnic groups, especially those with family histories, is needed to better understand the factors that impact teenagers’ empowerment in psychiatric genomic settings and to identify measures, including the best enablers of empowerment (e.g., educators, parents), which would allow them to reap the benefits of precision psychiatry.
Public Health Genomics

中文翻译：

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青少年和精准精神病学：机会之窗

目的：精准医学通过激发与健康相关的、降低风险的行为，为将有关精神风险的遗传知识转化为心理健康益处带来了希望。青少年（14-17 岁）是参与预防工作的重要年龄组，但他们对精神遗传学的看法尚未得到充分研究。方法：对具有全国代表性的青少年样本（ n = 417）进行了在线调查。参与者被随机分配接受 2 份讲义中的 1 份，其中 1 份强调精神疾病的遗传基础；1 份强调精神疾病的遗传基础；2 份强调精神疾病的遗传基础。另一种则以机构为导向，重点关注基因与环境的相互作用。调查问题询问了他们对因精神遗传风险信息而发生的行为改变的看法，并表示愿意采取这些措施。参与者的决策特征（即自我效能、赋权、不能容忍不确定性和寻求感觉）在基线时进行评估。结果：青少年非常重视所提供的信息及其对心理健康的潜在有用性。仅有关精神遗传学的信息就影响了人们对精神疾病原因的看法。与我们的假设相反，施舍的类型并没有影响参与者表达的改变行为以降低患精神疾病风险的意愿，但他们的赋权感在他们的反应中发挥了关键作用。结论：对青少年进行有关基因与环境相互作用的教育可能有助于促进精准精神病学的转化工作。需要对跨种族/族裔群体的青少年，特别是有家族史的青少年进行研究，以更好地了解影响青少年在精神基因组环境中赋权的因素，并确定措施，包括赋权的最佳推动者（例如教育工作者、父母）、这将使他们获得精准精神病学的好处。
公共卫生基因组学