当前位置: X-MOL 学术Neuroimmunomodulation › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
The Effect of Exercise and Psychological Stress on Anti- and Proinflammatory Cytokines
Neuroimmunomodulation ( IF 2.4 ) Pub Date : 2021-01-27 , DOI: 10.1159/000512814
Sara Hasanli 1 , Sarah Hojjati 2 , Maryam Koushkie Jahromi 3
Affiliation  

Background/Aims: Research evidence regarding immune system responses and adaptations to psychological or physical stresses is controversial. This study aimed to investigate the effect of 8-week psychological stress and exercise activity (chronic adaptation) and the acute response of possibly adapted rats to psychological stress and exercise considering IFN-γ, IL-4, and IL-4/IFN-γ. Methods: Thirty-two rats were divided into 4 groups of 8 animals including control, exercise, psychological stress, and combination of exercise with psychological stress. IL-4 and IFN-γ cytokines were measured pre-experiment (preEX), immediately postexercise (IpostEX), and 72-h postexperiment protocol (72hpostEX). Results: There were no significant differences between the study groups regarding IFN-γ, IL-4, and IL-4/IFN-γ in preEX (p #x3e; 0.05), IpostEX (p #x3e; 0.05), and 72hpostEX (p #x3e; 0.05). However, IL-4 increased significantly in IpostEX compared with preEX in exercise (p = 0.012) and combination of exercise with psychological stress (p = 0.03) groups. Conclusions: Exercise and combination of exercise and psychological stress induce similar acute response to IL-4 in chronic trained and stressed rats. Also, exercise may induce an acute synergistic effect with psychological stress on IL-4.
Neuroimmunomodulation


中文翻译:

运动和心理压力对抗炎和促炎细胞因子的影响

背景/目的:关于免疫系统反应和适应心理或生理压力的研究证据是有争议的。本研究旨在探讨 8 周心理压力和运动活动(慢性适应)的影响,以及考虑 IFN-γ、IL-4 和 IL-4/IFN-γ 的可能适应的大鼠对心理压力和运动的急性反应. 方法:将32只大鼠分为对照组、运动组、心理应激组、运动与心理应激相结合4组,每组8只。IL-4 和 IFN-γ 细胞因子在实验前 (preEX)、运动后立即 (IpostEX) 和实验后 72 小时 (72hpostEX) 进行测量。结果:研究组之间在 preEX ( p #x3e; 0.05)、IpostEX ( p #x3e; 0.05) 和 72hpostEX ( p # x3e;0.05)。然而,与运动前EX相比,IpostEX中IL-4显着增加(p = 0.012)和运动与心理压力相结合(p = 0.03)组。结论:运动以及运动和心理压力的组合在慢性训练和压力的大鼠中诱导类似的对 IL-4 的急性反应。此外,运动可能会与心理压力对 IL-4 产生急性协同作用。
神经免疫调节
更新日期:2021-01-27
down
wechat
bug