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Electrodecoration and Characterization of Superparamagnetic Iron Oxide Nanoparticles with Bioactive Synergistic Nanocopper: Magnetic Hyperthermia-Induced Ionic Release for Anti-Biofilm Action
Antibiotics ( IF 4.8 ) Pub Date : 2021-01-27 , DOI: 10.3390/antibiotics10020119
Verdiana Marchianò , Maria Salvador , Amanda Moyano , Gemma Gutiérrez , María Matos , Susana Yáñez-Vilar , Yolanda Piñeiro , José Rivas , José C. Martínez-García , Davide Peddis , Maria C. Blanco-López , Montserrat Rivas , Nicoletta Ditaranto , Nicola Cioffi

The urgency for the availability of new antibacterial/disinfectant agents has become a worldwide priority. At the same time, along with the extensive use of other metal nanoparticles (NPs), the investigation of magnetic NPs (MNPs) in antibacterial studies has turned out to be an increasingly attractive research field. In this context, we present the preparation and characterization of superparamagnetic iron oxide NPs, electrodecorated with antimicrobial copper NPs, able to modulate the release of bioactive species not only by the NP’s stabilizer, but also through the application of a suitable magnetic field. Antimicrobial synergistic CuNPs stabilized by benzalkonium chloride have been used in the current study. We demonstrate the successful preparation of 3O4 MNPs composites through morphological and spectroscopic results. Additionally, an extensive magnetic characterization is reported, along with hyperthermia-induced copper ionic release. On the basis of our results, we propose a new generation of antimicrobial magnetic nanomaterials, whose bioactivity can be also tuned by the application of a magnetic field. View Full-Text

中文翻译:

具有生物活性协同纳米铜的超顺磁性氧化铁纳米粒子的电修饰和表征:磁热诱导的离子释放,以抗生物膜作用。

获得新的抗菌/消毒剂的紧迫性已成为世界范围的优先考虑。同时,随着其他金属纳米颗粒(NPs)的广泛使用,在抗菌研究中对磁性NPs(MNPs)的研究已成为越来越有吸引力的研究领域。在这种情况下,我们介绍了超顺磁性氧化铁纳米粒子的制备和表征,这些纳米粒子与抗菌铜纳米粒子电连接,不仅可以通过纳米粒子的稳定剂而且可以通过施加合适的磁场来调节生物活性物质的释放。在当前的研究中已使用通过苯扎氯铵稳定的抗菌协同CuNP。我们证明了3 O 4的成功制备MNPs通过形态学和光谱学结果合成。此外,据报道,广泛的磁特性以及热疗诱导的铜离子释放。根据我们的结果,我们提出了新一代的抗菌磁性纳米材料,其生物活性也可以通过施加磁场来调节。查看全文
更新日期:2021-01-27
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