ABSTRACT

Oncogenic viruses are associated with approximately 15% of human cancers. In viral infections, microRNAs play an important role in host-pathogen interactions. miR-21 is a highly conserved non-coding RNA that not only regulates the development of oncogenic viral diseases, but also responds to the regulation of intracellular signal pathways. Oncogenic viruses, including HBV, HCV, HPV, and EBV, co-evolve with their hosts and cause persistent infections. The upregulation of host miR-21 manipulates key cellular pathways to evade host immune responses and then promote viral replication. Thus, a better understanding of the role of miR-21 in viral infections may help us to develop effective genetically-engineered oncolytic virus-based therapies against cancer.

摘要

致癌病毒与大约 15% 的人类癌症有关。在病毒感染中，microRNA 在宿主-病原体相互作用中起重要作用。miR-21是一种高度保守的非编码RNA，不仅调节致癌病毒疾病的发展，而且响应细胞内信号通路的调节。包括 HBV、HCV、HPV 和 EBV 在内的致癌病毒与宿主共同进化并导致持续感染。宿主 miR-21 的上调操纵关键的细胞途径来逃避宿主免疫反应，然后促进病毒复制。因此，更好地了解 miR-21 在病毒感染中的作用可能有助于我们开发有效的基于基因工程溶瘤病毒的抗癌疗法。