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A Systems View of the Heparan Sulfate Interactome
Journal of Histochemistry & Cytochemistry ( IF 3.2 ) Pub Date : 2021-01-26 , DOI: 10.1369/0022155420988661
Alejandro Gómez Toledo 1, 2, 3 , James T Sorrentino 4, 5 , Daniel R Sandoval 1, 2 , Johan Malmström 3 , Nathan E Lewis 5, 6 , Jeffrey D Esko 1, 2
Affiliation  

Heparan sulfate proteoglycans consist of a small family of proteins decorated with one or more covalently attached heparan sulfate glycosaminoglycan chains. These chains have intricate structural patterns based on the position of sulfate groups and uronic acid epimers, which dictate their ability to engage a large repertoire of heparan sulfate–binding proteins, including extracellular matrix proteins, growth factors and morphogens, cytokines and chemokines, apolipoproteins and lipases, adhesion and growth factor receptors, and components of the complement and coagulation system. This review highlights recent progress in the characterization of the so-called “heparan sulfate interactome,” with a major focus on systems-wide strategies as a tool for discovery and characterization of this subproteome. In addition, we compiled all heparan sulfate–binding proteins reported in the literature to date and grouped them into a few major functional classes by applying a networking approach.



中文翻译:

硫酸乙酰肝素相互作用组的系统观点

硫酸乙酰肝素蛋白聚糖由一小类蛋白质组成,这些蛋白质被一条或多条共价连接的硫酸乙酰肝素糖胺聚糖链修饰。这些链具有基于硫酸基团和糖醛酸差向异构体位置的复杂结构模式,这决定了它们能够结合大量硫酸乙酰肝素结合蛋白,包括细胞外基质蛋白、生长因子和形态发生素、细胞因子和趋化因子、载脂蛋白和脂肪酶、粘附和生长因子受体以及补体和凝血系统的成分。这篇综述强调了所谓的“硫酸乙酰肝素相互作用组”表征的最新进展,重点关注作为发现和表征该亚蛋白质组的工具的全系统策略。此外,我们编译了迄今为止文献中报道的所有硫酸乙酰肝素结合蛋白,并通过应用网络方法将它们分为几个主要功能类别。

更新日期:2021-01-26
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