Glioblastoma multiforme (GBM) is a highly malignant and rapidly advancing astrocytic brain tumor in adults. Current therapy possibilities are chemotherapy, surgical resection, and radiation. The complexity of drug release through the blood-brain barrier, tumor reaction to chemotherapy, and the inherent resistance of tumor cells present challenges. New therapies are needed for individual use or combination with conventional methods for more effective treatment and improved survival for patients. GBM is difficult to treat because it grows quickly, spreads finger-shaped tentacles, and creates an irregular margin of normal tissue surrounding the tumor. Non-thermal biocompatible plasma (NBP) has recently been shown to selectively target cancer cells with minimal effects on regular cells, acting by generating reactive oxygen species (ROS) and reactive nitrogen species (RNS). We applied a soft jet plasma device with a syringe shape to U87 MG cells and astrocytes. Our results show that NBP-J significantly inhibits cell proliferation and changes morphology, induces cell cycle arrest, inhibits the survival pathway, and induces apoptosis. Our results indicate that NBP-J may be an efficient and safe clinical device for brain cancer therapy.

中文翻译：

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非热生物相容性等离子体射流诱导脑癌细胞凋亡

多形性胶质母细胞瘤 (GBM) 是一种高度恶性且进展迅速的成人星形胶质细胞脑肿瘤。目前的治疗可能性是化疗、手术切除和放疗。通过血脑屏障释放药物的复杂性、肿瘤对化疗的反应以及肿瘤细胞的固有耐药性都带来了挑战。需要新疗法单独使用或与传统方法结合使用，以实现更有效的治疗并提高患者的生存率。GBM 难以治疗，因为它生长迅速，散布手指状触手，并在肿瘤周围形成不规则的正常组织边缘。非热生物相容性血浆 (NBP) 最近已被证明可以选择性地靶向癌细胞，而对常规细胞的影响最小，通过产生活性氧 (ROS) 和活性氮 (RNS) 来发挥作用。我们将注射器形状的软喷射等离子体装置应用于 U87 MG 细胞和星形胶质细胞。我们的结果表明，NBP-J 显着抑制细胞增殖和改变形态，诱导细胞周期停滞，抑制存活途径，并诱导细胞凋亡。我们的研究结果表明，NBP-J 可能是一种有效且安全的脑癌治疗临床设备。