ABSTRACT

This study investigated behavioral phenotype, executive functions profile, and the existence of comorbid psychiatric disorders in children and adolescents with methylenetetrahydrofolate reductase (MTHFR) polymorphisms admitted to pediatric metabolism outpatient clinic. Internalizing problems, especially somatic complaints were common in patients with MTHFR. More than half of the cases had emotional control and initiating problems as executive function deficits. Attention-deficit/hyperactivity disorder was the most common psychiatric diagnosis, followed by anxiety disorder. Current findings emphasize that health care providers should be aware of the mental health needs of cases with MTHFR polymorphism in order to make plans of integrative physical and mental health care.

摘要

这项研究调查了儿童和青少年亚甲基四氢叶酸还原酶（MTHFR）多态性入院儿科门诊就诊的儿童的行为表型，执行功能状况以及合并精神病的情况。内在化问题，尤其是躯体主诉在MTHFR患者中很常见。一半以上的病例由于执行功能缺陷而情绪控制和引发问题。注意缺陷/多动障碍是最常见的精神病学诊断，其次是焦虑症。当前的研究结果强调，医疗保健提供者应了解MTHFR多态性病例的心理健康需求，以便制定综合的身心保健计划。