Properties and functions of various ZnO materials are intensively investigated in biological systems for diagnostics, therapy, health risks assessment as well as bactericidal and decontamination purposes. Herein, the interface between ZnO and biological environment is studied by characterizing adsorption of bovine serum albumin (BSA) and fetal bovine serum (FBS) using atomic force microscopy with CF₄‐treated tips. Similar molecular morphologies (thickness around 2 nm) yet different binding forces to ZnO (10–25 nN) are observed. These observations are corroborated by atomic scale simulations of BSA on (0001) ZnO surface using force‐field method and showing rearrangements of Zn surface atoms. Such binding may have an impact also on other properties of ZnO–BSA complex.

中文翻译：

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牛血清白蛋白在氧化锌（0001）表面的吸附的微观研究

为了诊断，治疗，健康风险评估以及杀菌和去污目的，在生物系统中对各种ZnO材料的特性和功能进行了深入研究。本文中，通过使用CF ₄处理的尖端的原子力显微镜表征牛血清白蛋白（BSA）和胎牛血清（FBS）的吸附特性，研究了ZnO与生物环境之间的界面。观察到相似的分子形态（厚度约2 nm），但与ZnO的结合力不同（10-25 nN）。这些观察结果通过使用力场法在（0001）ZnO表面上对BSA进行原子级模拟得到了证实，并显示了Zn表面原子的重排。这种结合也可能对ZnO-BSA复合物的其他性能产生影响。