Five new tyrosine derivatives (1–5), one new phenylacetic acid derivative (6), two new quinazolinone analogues (7 and 8), one new naphthalenedicarboxylic acid (9), and one new 3,4-dihydroisocoumarin derivative (10), together with seven known compounds, were isolated from the fungus Xylaria sp. FM1005, which was isolated from Sinularia densa (leather coral) collected in the offshore region of the Big Island, Hawaii. The structures of compounds 1–10 were elucidated by extensive analysis of NMR spectroscopy, HRESIMS, and ECD data. Due to their structure similarity to the antiplatelet drug tirofiban, compounds 1–5 together with 6 were investigated for their antithrombotic activities. Compounds 1 and 2 strongly inhibited the binding of fibrinogen to purified integrin IIIb/IIa in a dose-dependent manner with the IC₅₀ values of 0.89 and 0.61 μM, respectively, and compounds 1 and 2 did not show any cytotoxicity against A2780 and HEK 293 at 40 μM.

中文翻译：

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来自皮革珊瑚的真菌菌株 Xylaria sp. 的次生代谢物。FM1005 及其糖蛋白 IIb/IIIa 抑制活性

五种新的酪氨酸衍生物 ( 1 – 5 )、一种新的苯乙酸衍生物 ( 6 )、两种新的喹唑啉酮类似物 ( 7和8 )、一种新的萘二甲酸 ( 9 ) 和一种新的 3,4-二氢异香豆素衍生物 ( 10 )，连同七种已知化合物，从真菌Xylaria sp.中分离出来。FM1005，它是从夏威夷大岛近海地区收集的Sinularia densa（皮革珊瑚）中分离出来的。化合物的结构1 - 10通过对 NMR 光谱、HRESIMS 和 ECD 数据的广泛分析来阐明。由于它们的结构相似性的抗血小板药物替罗非班，化合物1 - 5连同6进行了调查其抗血栓形成活性。化合物1和2以剂量依赖性方式强烈抑制纤维蛋白原与纯化的整合素 IIIb/IIa 的结合，IC ₅₀值分别为 0.89 和 0.61 μM，化合物1和2对 A2780 和 HEK 293 没有显示任何细胞毒性在 40 微米。