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Retinal and Choroidal Thickness in relation to C-Reactive Protein on Swept-Source Optical Coherence Tomography
Journal of Immunology Research ( IF 4.1 ) Pub Date : 2021-01-25 , DOI: 10.1155/2021/6628224 Dawei Fang 1 , Qingjian Li 2, 3, 4, 5 , Ke Yan 3, 4, 5 , Sennan Xu 3, 4, 5 , Jing Jiang 2 , Xin Che 2 , Yu Zhang 2 , Yiwen Qian 2 , Zhiliang Wang 2
Journal of Immunology Research ( IF 4.1 ) Pub Date : 2021-01-25 , DOI: 10.1155/2021/6628224 Dawei Fang 1 , Qingjian Li 2, 3, 4, 5 , Ke Yan 3, 4, 5 , Sennan Xu 3, 4, 5 , Jing Jiang 2 , Xin Che 2 , Yu Zhang 2 , Yiwen Qian 2 , Zhiliang Wang 2
Affiliation
Purpose. To evaluate the relationships between C-reactive protein (CRP) and retinal and choroidal thickness by swept-source optical coherence tomography (SS-OCT). Methods. The participants included in the prospective cross-sectional study underwent a comprehensive ophthalmic examination. Based on the CRP values, the subjects were divided into the CRP (+) group ( mg/L) and the CRP (−) group ( mg/L). The retinal and choroidal thickness was compared between the two groups. Results. This study enrolled 43 right eyes of 43 subjects from the CRP (+) group and 86 right eyes of 86 gender- and age-match subjects from the CRP (−) group. The choroidal thickness in the CRP (+) group was thinner than that in the CRP (−) group except for the outer nasal sector of the Early Treatment Diabetic Retinopathy Study (ETDRS) grid. However, the retinal thickness only in the inner temporal sector showed a significant difference. According to Pearson’s correlation analysis, the CRP was significantly negatively correlated with the choroidal thickness in all sectors and the retinal thickness only in the inner temporal and outer nasal sectors of the ETDRS grid. Conclusion. CRP levels are associated with retinal and choroidal thickness. The data related to the retinal and choroidal thickness changes may help understand the pathogenesis of specific ocular abnormalities in patients with systemic inflammation.
中文翻译:
扫描源光学相干断层扫描与 C 反应蛋白相关的视网膜和脉络膜厚度
目的。通过扫描源光学相干断层扫描 (SS-OCT) 评估 C 反应蛋白 (CRP) 与视网膜和脉络膜厚度之间的关系。方法。前瞻性横断面研究中的参与者接受了全面的眼科检查。根据 CRP 值,将受试者分为 CRP(+)组( mg/L) 和 CRP (-) 组 ( 毫克/升)。比较两组的视网膜和脉络膜厚度。结果。该研究招募了来自 CRP (+) 组的 43 名受试者的 43 只右眼和来自 CRP (-) 组的 86 名性别和年龄匹配受试者的 86 只右眼。除了早期治疗糖尿病视网膜病变研究 (ETDRS) 网格的外鼻部分外,CRP (+) 组的脉络膜厚度比 CRP (-) 组的薄。然而,仅在内侧颞区的视网膜厚度显示出显着差异。根据 Pearson 的相关性分析,CRP 与所有扇区的脉络膜厚度显着负相关,仅在 ETDRS 网格的内颞和外鼻扇区中的视网膜厚度显着负相关。结论. CRP 水平与视网膜和脉络膜厚度有关。与视网膜和脉络膜厚度变化相关的数据可能有助于了解全身炎症患者特定眼部异常的发病机制。
更新日期:2021-01-25
中文翻译:
扫描源光学相干断层扫描与 C 反应蛋白相关的视网膜和脉络膜厚度
目的。通过扫描源光学相干断层扫描 (SS-OCT) 评估 C 反应蛋白 (CRP) 与视网膜和脉络膜厚度之间的关系。方法。前瞻性横断面研究中的参与者接受了全面的眼科检查。根据 CRP 值,将受试者分为 CRP(+)组( mg/L) 和 CRP (-) 组 ( 毫克/升)。比较两组的视网膜和脉络膜厚度。结果。该研究招募了来自 CRP (+) 组的 43 名受试者的 43 只右眼和来自 CRP (-) 组的 86 名性别和年龄匹配受试者的 86 只右眼。除了早期治疗糖尿病视网膜病变研究 (ETDRS) 网格的外鼻部分外,CRP (+) 组的脉络膜厚度比 CRP (-) 组的薄。然而,仅在内侧颞区的视网膜厚度显示出显着差异。根据 Pearson 的相关性分析,CRP 与所有扇区的脉络膜厚度显着负相关,仅在 ETDRS 网格的内颞和外鼻扇区中的视网膜厚度显着负相关。结论. CRP 水平与视网膜和脉络膜厚度有关。与视网膜和脉络膜厚度变化相关的数据可能有助于了解全身炎症患者特定眼部异常的发病机制。