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Armochaetoglasins J and K: new cytochalasans from Chaetomium globosum
Natural Product Research ( IF 2.2 ) Pub Date : 2021-01-25 , DOI: 10.1080/14786419.2021.1872568
Li Cheng 1 , Xi Zheng 1 , Qin Li 2 , Meng-Sha Wei 2 , Chun-Mei Chen 2 , Hu-Cheng Zhu 2 , Chang-Li Zeng 3 , Xin-Cai Hao 1 , Yong-Hui Zhang 2
Affiliation  

Abstract

Two novel cytochalasans, armochaetoglasin J (1) and armochaetoglasin K (2), along with 14 known analogues (316) were isolated from Chaetomium globosum. Their structures were elucidated by HRESIMS, NMR spectroscopy, single-crystal X-ray crystallography, and ECD spectra. Armochaetoglasins J and K were found to be inactive against the HepG2, HT-29, K562, HL-60, and A549 cancer cell lines.



中文翻译:

Armochaetoglasins J 和 K:来自球毛壳菌的新细胞松弛素

摘要

从球毛壳菌中分离出两种新的细胞松弛素,armochaetoglasin J ( 1 ) 和armochaetoglasin K ( 2 ) ,以及 14 种已知的类似物 ( 3-16 ) 通过 HRESIMS、NMR 光谱、单晶 X 射线晶体学和 ECD 光谱阐明了它们的结构。发现 Armochaetoglasins J 和 K 对 HepG2、HT-29、K562、HL-60 和 A549 癌细胞系无活性。

更新日期:2021-01-25
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