Cardiovascular diseases are associated with high incidence and mortality, contribute to disability and place a heavy economic burden on countries worldwide. Stimulating endogenous cardiomyocyte proliferation and regeneration has been considering as a key to repair the injured heart caused by ischaemia. Emerging evidence has proved that non‐coding RNAs participate in cardiac proliferation and regeneration. In this review, we focus on the observation and mechanism that microRNAs (or miRNAs), long non‐coding RNAs (or lncRNAs) and circular RNA (or circRNAs) regulate cardiomyocyte proliferation and regeneration to repair a damaged heart. Furthermore, we highlight the potential therapeutic role of some non‐coding RNAs used in stimulating CMs proliferation. Finally, perspective on the development of non‐coding RNAs therapy in cardiac regeneration is presented.

中文翻译：

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心肌细胞增殖和心脏再生中的非编码 RNA：剖析其治疗价值

心血管疾病与高发病率和死亡率相关，导致残疾，并给世界各国带来沉重的经济负担。刺激内源性心肌细胞增殖和再生一直被认为是修复因缺血引起的损伤心脏的关键。新出现的证据证明非编码 RNA 参与心脏增殖和再生。在这篇综述中，我们重点关注 microRNA（或 miRNA）、长链非编码 RNA（或 lncRNA）和环状 RNA（或 circRNA）调节心肌细胞增殖和再生以修复受损心脏的观察和机制。此外，我们强调了一些用于刺激 CMs 增殖的非编码 RNA 的潜在治疗作用。最后，