Acoustic manipulation has a series of application in biomedicine, colloidal assembly, and chemistry. A three-layered polymer capsule is generally used structure in manipulation system because it has better protection to the core filled drug or compounds and possesses higher flexibility. In this paper, a theoretical model of acoustic radiation force acting on a three-layered drug capsule in a vessel is established. The acoustic radiation force on a capsule, which comprises of a drug core, a poly(lactide-co-glycolide) mid shell and a chitosan outer shell in the cylindrical tube filled with ideal fluid, is calculated using acoustic wave theory. The influences of the tube, the surrounding fluid and the geometric size of chitosan, poly(lactide-co-glycolide) shell and drug core on acoustic radiation force are investigated. The numerical simulations based on finite element method are introduced to compute the acoustic radiation force and compared with the analytical results. Moreover, the comparison among the capsule in impedance tube, in rigid tube and in unbounded space is obtained simulating specific environment. Simulation results show that the influences of the rigid tube on the acoustic radiation force of the capsule can be ignored when the capsule is much smaller than the radius of the tube. With the increase of the capsule radius, the acoustic radiation force of the capsule changes demonstrably with the frequency and the tube radius because of the influence of the reflective wave resulted from the inner surface of the tube. The properties of the surrounding fluid affect the position of the resonant peaks. Outer radius and mid layer radius have more effects on the acoustic radiation force, but the drug core radius almost exerts no effect on it. The study illustrates that the capsule can be manipulated by acoustic wave with the suitable selection for the outer or mid shell radii, and the selection of drug core radius is of more freedom in this process.

声学处理在生物医学，胶体组装和化学领域有一系列应用。三层聚合物胶囊在操纵系统中通常使用结构，因为它对核心填充药物或化合物具有更好的保护，并具有更高的柔韧性。本文建立了声辐射力作用于三层药物胶囊的理论模型。在胶囊的声辐射力，其包括药物核心的，聚（丙交酯-共-glycolide）中间壳和在所述圆柱形管内充满理想流体壳聚糖外壳中，使用声波理论计算。管，周围流体和壳聚糖，聚丙交酯共聚物的几何尺寸的影响-乙交酯）壳和药物核对声辐射力的影响。引入了基于有限元方法的数值模拟计算声辐射力，并与分析结果进行了比较。此外，通过模拟特定环境，获得了阻抗管，刚性管和无界空间中的胶囊之间的比较。仿真结果表明，当胶囊比管的半径小得多时，刚性管对胶囊的声辐射力的影响可以忽略。随着囊半径的增加，由于从管的内表面产生的反射波的影响，囊的声辐射力随着频率和管半径而明显地变化。周围流体的特性会影响共振峰的位置。外半径和中层半径对声辐射力的影响更大，但药心半径几乎对其没有影响。研究表明，可以通过声波来操纵胶囊，并选择外壳半径或中壳半径，在此过程中选择药心半径更为自由。