Neuroinflammation is a highly reactive response that has not been addressed due to its complexity. Some of its molecular pathways, such as glycosylation, have been neglected in the past. Despite the intricacy and diversity of the glycome, there has been an increased interest in this field of study, which has resulted in fostering advances in glycobiology and glycochemistry. These advances have supported the emergence of a new class of glyco-engineered approaches, in which biomaterial-based strategies can address different disease glycophenotypes. Even though these are not extensively used yet, this review aims to provide a resourceful toolbox to build a wide variety of novel materials that can be designed to tackle the glyco-dysregulations seen in neuroinflammation. By assembling the already-well-described knowledge from glycobiology and chemistry, the best of both worlds can be harnessed toward the emergence of a new biomaterial science branch of study: polymeric-based glyco-modulatory materials.

神经炎症是一种高度反应性的反应，由于其复杂性尚未得到解决。过去已经忽略了其某些分子途径，例如糖基化。尽管糖组的复杂性和多样性，但对这一研究领域的兴趣却在增加，这导致了糖生物学和糖化学的发展。这些进展支持了新一类的糖工程方法的出现，其中基于生物材料的策略可以解决不同的疾病糖表型。即使这些尚未得到广泛使用，本综述旨在提供一个资源丰富的工具箱，以构建各种新颖的材料，这些材料可用于解决神经炎症中所见的糖异常。通过整合已有的糖生物学和化学知识，