We have designed a new magnetic targeting drug carrier Fe₃O₄-PVA with a core of triiron tetroxide (Fe₃O₄) and a shell made of polyvinyl alcohol (PVA) to improve the hydrophilicity of Fe₃O₄. With adriamycin hydrochloride as a model drug, this study goes on to measure the drug carrier performance of Fe₃O₄-PVA. In addition, the thermal stability and enthalpy of thermal decomposition of Fe₃O₄-PVA were measured using a differential scanning calorimeter with a non-isothermal decomposition method. The kinetics of thermal decomposition of Fe₃O₄-PVA were also investigated. Over the course of this study, it was determined that the resulting drug carrier Fe₃O₄-PVA exhibited high drug loading levels and excellent release levels.

中文翻译：

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新型磁性靶向药物载体的制备及热分解动力学

我们设计了一种新型的磁性靶向药物载体Fe ₃ O ₄ -PVA，该载体具有四氧化_三铁（Fe ₃ O ₄）的芯和聚乙烯醇（PVA）制成的壳，以提高Fe ₃ O ₄的亲水性。以盐酸阿霉素为模型药物，本研究继续测量了Fe ₃ O ₄ -PVA的载药性能。另外，使用差示扫描量热计和非等温分解法测定了Fe ₃ O ₄ -PVA的热稳定性和热分解焓。Fe ₃ O ₄的热分解动力学-PVA也进行了调查。在本研究过程中，已确定所得的药物载体Fe ₃ O ₄ -PVA表现出高的药物载量水平和优异的释放水平。