当前位置: X-MOL 学术Immunol. Cell Biol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
The many faces of islet antigen‐specific CD8 T cells: clues to clinical outcome in type 1 diabetes
Immunology and Cell Biology ( IF 4 ) Pub Date : 2021-01-22 , DOI: 10.1111/imcb.12437
Alice E Wiedeman 1 , Cate Speake 2 , Sarah Alice Long 1
Affiliation  

Immune monitoring enables a better understanding of disease processes and response to therapy, but has been challenging in the setting of chronic autoimmunity because of unknown etiology, variable and protracted kinetics of the disease process, heterogeneity across patients and the complexity of immune interactions. To begin to parse this complexity, we focus here on type 1 diabetes (T1D) and CD8 T cells as a cell type that has features that are associated with different stages of disease, rates of progression and response to therapy. Specifically, we discuss the current understanding of the role of autoreactive CD8 T cells in disease outcome, which implicates particular CD8 functional subsets, rather than unique antigens or total number of autoreactive T cells. Next, we discuss how autoreactive CD8 T‐cell features can be reflected in measures of global CD8 T cells, and then pull these concepts together by highlighting immune therapies recently shown to modulate both CD8 T cells and disease progression. We end by discussing outstanding questions about the role of specific subsets of autoreactive CD8 T cells in disease progression and how they may be optimally modulated to treat and prevent T1D.

中文翻译:

胰岛抗原特异性 CD8 T 细胞的多面性:1 型糖尿病临床结果的线索

免疫监测有助于更好地了解疾病过程和对治疗的反应,但由于未知病因、疾病过程的可变和长期动力学、患者之间的异质性以及免疫相互作用的复杂性,在慢性自身免疫环境中一直具有挑战性。为了开始解析这种复杂性,我们将 1 型糖尿病 (T1D) 和 CD8 T 细胞作为一种细胞类型,其特征与疾病的不同阶段、进展速度和对治疗的反应有关。具体来说,我们讨论了目前对自身反应性 CD8 T 细胞在疾病结果中的作用的理解,这涉及特定的 CD8 功能子集,而不是独特的抗原或自身反应性 T 细胞的总数。下一个,我们讨论了自身反应性 CD8 T 细胞特征如何反映在全球 CD8 T 细胞的测量中,然后通过强调最近显示调节 CD8 T 细胞和疾病进展的免疫疗法将这些概念结合在一起。我们最后讨论了关于自身反应性 CD8 T 细胞特定亚群在疾病进展中的作用以及如何对它们进行最佳调节以治疗和预防 T1D 的突出问题。
更新日期:2021-01-22
down
wechat
bug