The physical exchange of DNA between homologs, crossing‐over, is essential to orchestrate the unique, reductional first meiotic division (MI). In females, the events of meiotic recombination that serve to tether homologs and facilitate their disjunction at MI occur during fetal development, preceding the MI division by several decades in our species. Data from studies in humans and mice demonstrate that placement of recombination sites during fetal development influences the likelihood of an MI nondisjunction event that results in the production of an aneuploid egg. Here we briefly summarize what we know about the relationship between aneuploidy and meiotic recombination and important considerations for the future of human assisted reproduction.

中文翻译：

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缺失的连接：重组和人类非整倍性

同源物之间 DNA 的物理交换、交叉对于协调独特的、减少的第一次减数分裂 (MI) 至关重要。在女性中，在胎儿发育期间，在我们物种的 MI 分裂之前几十年，发生减数分裂重组事件，这些事件用于系留同源物并促进它们在 MI 中的分离。来自人类和小鼠研究的数据表明，在胎儿发育过程中重组位点的放置会影响导致非整倍体卵产生的 MI 不分离事件的可能性。在这里，我们简要总结一下我们对非整倍体和减数分裂重组之间关系的了解以及对人类辅助生殖未来的重要考虑。