The Industry responsible for the discovery and development of crop protection compounds has undergone dramatic changes and increasing consolidation since the initial innovations in synthetic organic fungicides, herbicides and insecticides in the late 1940s and early 1950s. Likewise, there have been striking changes in the rate of introduction of new crop protection compounds over the past 70 years. While numerous studies over the past five decades have signaled the ongoing decline in the numbers of new active ingredients (AIs), a detailed analysis of the trends in the rate of introduction of crop protection compounds shows a more complex pattern in the overall output of new AIs. The recent (post-2000) decline in the numbers of new herbicides is the primary source of the perceived decline in overall numbers. When herbicides are excluded, the output of new fungicides and insecticides has been relatively constant, especially for the past 20 years. A notable observation is that innovation, as measured by the number of compounds representing a new chemical class (First-in-Class) has been relatively constant for the past 70 years, and most recently has been driven by the appearance of new fungicides and insecticides. Thus, the discovery and development of new AIs for crop protection and public health continues, in spite of the many challenges and changes to the Industry. © 2021 Society of Chemical Industry

中文翻译：

---

作物保护化合物——趋势和前景

自从 1940 年代末和 1950 年代初合成有机杀真菌剂、除草剂和杀虫剂的初步创新以来，负责发现和开发作物保护化合物的行业经历了巨大的变化和日益巩固的整合。同样，在过去 70 年中，新作物保护化合物的引入速度也发生了显着变化。虽然过去五年中的大量研究表明新活性成分 (AI) 的数量持续下降，但对作物保护化合物引入率趋势的详细分析表明，新活性成分的总产量呈现出更为复杂的模式。人工智能。最近（2000 年后）新除草剂数量的下降是总体数量下降的主要原因。排除除草剂后，新型杀菌剂和杀虫剂的产量一直相对稳定，特别是在过去的 20 年中。一个值得注意的观察结果是，在过去 70 年中，以代表新化学类别（一流）的化合物数量来衡量的创新一直相对稳定，并且最近受到新杀菌剂和杀虫剂的出现的推动. 因此，尽管行业面临许多挑战和变化，但用于作物保护和公共卫生的新 AI 的发现和开发仍在继续。© 2021 化学工业协会 最近，新的杀菌剂和杀虫剂的出现推动了这一趋势。因此，尽管行业面临许多挑战和变化，但用于作物保护和公共卫生的新 AI 的发现和开发仍在继续。© 2021 化学工业协会 最近，新的杀菌剂和杀虫剂的出现推动了这一趋势。因此，尽管行业面临许多挑战和变化，但用于作物保护和公共卫生的新 AI 的发现和开发仍在继续。© 2021 化学工业协会