Combined Etanercept, GAD-alum and vitamin D treatment: an open pilot trial to preserve beta cell function in recent onset type 1 diabetes,Diabetes/Metabolism Research and Reviews

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Combined Etanercept, GAD-alum and vitamin D treatment: an open pilot trial to preserve beta cell function in recent onset type 1 diabetes
Diabetes/Metabolism Research and Reviews ( IF 8 ) Pub Date : 2021-01-24 , DOI: 10.1002/dmrr.3440
Johnny Ludvigsson ₁ , Indusmita Routray ₂ , Tore Vigård _{3,

4} , Ragnar Hanås _{5,

6} , Björn Rathsman ₇ , Annelie Carlsson _{8,

9} , Stefan Särnblad ₁₀ , Anna-Karin Albin ₁₁ , Carl-Göran Arvidsson ₁₂ , Ulf Samuelsson ₁ , Rosaura Casas ₂

Affiliation

Department of Biomedical and Clinical Sciences, Crown Princess Victoria Children´s Hospital and Division of Pediatrics, Linköping University, Linköping, Sweden.
Department of Biomedical and Clinical Sciences, Division of Pediatrics, Linköping University, Linköping, Sweden.
Department of Clinical Sciences, Pediatric Endocrinology, Lund University, Malmö, Sweden.
Department of Pediatrics, Skåne University Hospital, Malmö, Sweden.
Department of Pediatrics, NU Hospital Group, Uddevalla, Sweden.
Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Sachska Pediatric Hospital, Södersjukhuset, Stockholm, Sweden.
Department of Clinical Sciences, Pediatric Autoimmunity, Lund University, Lund, Sweden.
Skåne University Hospital, Lund, Sweden.
Department of Pediatrics, University Hospital, Örebro, Sweden.
Department of Pediatrics, Helsingborg Central Hospital, Helsingborg, Sweden.
Department of Pediatrics, Västerås Central Hospital, Västerås, Sweden.

We aimed to study the feasibility and tolerability of a combination therapy consisting of glutamic acid decarboxylase (GAD-alum), Etanercept and vitamin D in children and adolescents with newly diagnosed with type 1 diabetes (T1D), and evaluate preservation of beta cell function.

中文翻译：

依那西普、GAD-明矾和维生素 D 联合治疗：一项在近期发病的 1 型糖尿病中保持 β 细胞功能的公开试验性试验

我们旨在研究由谷氨酸脱羧酶 (GAD-alum)、依那西普和维生素 D 组成的联合疗法在新诊断为 1 型糖尿病 (T1D) 的儿童和青少年中的可行性和耐受性，并评估 β 细胞功能的保存情况。

更新日期：2021-01-24

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