Low-intensity pulsed ultrasound (LIPUS) with an intensity (spatial average temporal average, I_SATA) of 30 mW/cm² has been widely proved to be effective on impaired bone healing, but showing little effectiveness in the treatment of osteoporosis. We hypothesized that the intensity of LIPUS may be a key factor in explaining this difference, thus two intensity levels, the widely used 30 mW/cm² and a higher 150 mW/cm², were used to simultaneously treat osteoporosis and osteoporotic bone defect in ovariectomized (OVX) rats with a 1-mm drill hole on their left femurs. Results showed that 150 mW/cm² LIPUS augmented the healing rate of the drill hole than 30 mW/cm² after 3-week LIPUS treatment, although did not further enhance the healing rate after 6-week LIPUS treatment. For ameliorating osteoporosis, 150 mW/cm² LIPUS achieved more advantages over 30 mW/cm² in improving bone density, microstructure and biomechanics 6 weeks after LIPUS intervention. In conclusion, LIPUS with an intensity of 30 mW/cm² was sufficient to facilitate bone defect healing, but a higher intensity can be considered as a rapid trigger for osteoporotic bone repair. In addition, improving the intensity of LIPUS may be a potentially effective consideration for alleviation of osteoporosis, and the LIPUS regimen in the treatment of osteoporosis remains to be optimized.

强度（空间平均时间平均，I _SATA）为30 mW / cm ^2的低强度脉冲超声（LIPUS）已被广泛证明对受损骨愈合有效，但在治疗骨质疏松症方面几乎没有效果。我们假设LIPUS的强度可能是解释这种差异的关键因素，因此，两种强度水平，广泛使用的30 mW / cm ²和更高的150 mW / cm ²被用于同时治疗骨质疏松和骨质疏松性骨缺损。去卵巢（OVX）大鼠的左股骨上有一个1毫米的钻孔。 结果表明，与30 mW / cm ²相比，150 mW / cm ^2的LIPUS可以提高钻孔的愈合率经过3周LIPUS治疗后，尽管没有进一步提高6周LIPUS治疗后的治愈率。为了改善骨质疏松症，LIPUS干预后6周，与30 mW / cm ²相比，150 mW / cm ^2的LIPUS在改善骨密度，微结构和生物力学方面取得了更多优势。总之，强度为30 mW / cm ^2的LIPUS足以促进骨缺损的愈合，但是较高的强度可以认为是骨质疏松性骨修复的快速触发因素。另外，改善LIPUS的强度可能是减轻骨质疏松症的潜在有效考虑，并且在骨质疏松症治疗中的LIPUS方案仍有待优化。