Acetaminophen (APAP) is used as a primary medication in relieving moderate pain and fever. However, APAP is associated with toxic effects in renal tissue that appear because of its free radicals property. The principle goal of the present work is to assess the kidney damage by APAP and its restore antioxidative property of cinnamon oil (CO). Animals were distributed into six animals each in six groups. Rats were administered with three varying doses of CO from 50 to 200 mg/kg b.w. respectively and only a single dose of APAP. APAP induced an alteration in serum biochemical markers, imbalance in oxidative parameters, morphological changes in kidney tissue along with increased interleukins cytokines (IL-1β & 6) and caspase (3, 9) levels. CO administration significantly ameliorates all the parameters and histopathological changes were restored. Moreover, it also restored the activities of antioxidative enzymes. Our work proved that an variance of oxidative markers in the kidney by APAP is ameliorated by CO in rats. Thus, CO could be used in reducing APAP-induced nephrotoxicity.

对乙酰氨基酚 (APAP) 用作缓解中度疼痛和发烧的主要药物。然而，APAP 由于其自由基特性而与肾组织中出现的毒性作用相关。目前工作的主要目标是评估 APAP 对肾脏的损害及其恢复肉桂油 (CO) 的抗氧化性能。将动物分成六组，每组六只。给大鼠施用三种不同剂量的CO，分别为50至200mg/kg体重，并且仅施用单剂量的APAP。APAP 引起血清生化标志物的改变、氧化参数的不平衡、肾组织的形态变化以及白细胞介素细胞因子 (IL-1β 和 6) 和半胱天冬酶 (3, 9) 水平的增加。CO 给药显着改善了所有参数并且组织病理学变化得到恢复。此外，它还恢复了抗氧化酶的活性。我们的工作证明，大鼠肾脏中由 APAP 引起的氧化标记物的变化可通过 CO 得到改善。因此，CO 可用于减少 APAP 诱导的肾毒性。