A marine actinomycete strain C1-2 was taxonomically characterized as the genus Streptomyces, based on whole-genome sequence analysis. The highest average nucleotide identity (ANI) value (98.96%) and digital DNA–DNA hybridization (DDH) value (90.4%) were observed between Streptomyces sp. C1-2 and Streptomyces griseoaurantiacus. Thus, Streptomyces sp. C1-2 could be identified as S. griseoaurantiacus. Genome analysis revealed that Streptomyces sp. C1-2 contained 22 biosynthetic gene clusters (BGCs) for secondary metabolites, where among them, 54% have low similarities with known BGCs. The chemical investigation led to the isolation of three new manumycin-type derivatives and two known analog antibiotics named SW-B and cornifronin B. All compounds showed antioxidant activity with the half-maximal inhibitory concentration (IC₅₀) values in a range of 50.82 ± 0.8–112.04 ± 1.0 μg/mL with no cytotoxicity against Vero cells. This is the first report of the antioxidant property of manumycin-type derivatives. Moreover, two known compounds exhibited antifungal activity against Phytophthora capsici, Fusarium oxysporum f. sp. cucumerinum, and Magnaporthe grisea, with the minimum inhibitory concentration (MIC) values in a range of 125–500 μg/mL.

基于全基因组序列分析，海洋放线菌菌株 C1-2 在分类学上被定性为链霉菌属。在链霉菌属物种之间观察到最高的平均核苷酸同一性 (ANI) 值 (98.96%) 和数字 DNA-DNA 杂交 (DDH) 值 (90.4%) 。C1-2 和Streptomyces griseoaurantiacus。因此，链霉菌属。C1-2 可以被鉴定为S. griseoaurantiacus。基因组分析表明链霉菌sp. C1-2 包含 22 个次级代谢产物的生物合成基因簇 (BGC)，其中 54% 与已知 BGC 的相似度较低。化学研究导致分离出三种新的马努霉素类衍生物和两种已知的类似抗生素，名为 SW-B 和可尼弗宁 B。所有化合物均显示出抗氧化活性，半数抑制浓度 (IC ₅₀ ) 值范围为 50.82 ± 0.8–112.04 ± 1.0 μg/mL，对 Vero 细胞无细胞毒性。这是首次报道了马努霉素类衍生物的抗氧化性能。此外，两种已知化合物对辣椒疫霉、尖孢镰刀菌( Fusarium oxysporum f)表现出抗真菌活性。sp. 黄瓜，和Magnaporthe grisea，最低抑菌浓度( MIC ) 值在 125–500 μg/mL 范围内。