Background

Signs of contralateral hemispatial inattention may be witnessed in children following perinatal brain infarcts (lesions), and evidence shows a pattern distinct from that in adults. This study is a longitudinal analysis of children with perinatal infarcts, with the goals of determining the pattern of inattention found in children with left or right hemisphere lesions and whether this pattern shows signs of change over time.

Methods

Twenty-one children with left hemishpere lesions, nine children with right hemisphere lesions, and 80 neurologically healthy control children were given the Infant and Toddler Neglect Task at two different time points. At time 1, median age was 1.54 years (interquartile range [IQR] = 0.92 to 2.29). At time 2, median age was 3.25 years (IQR = 2.23 to 5.00). A standardized scoring system was developed to compare the children’s preference for the left versus right side of space.

Results

Children with left hemisphere lesions showed a significantly increased preference for the left side of space and a slightly decreased preference for the right side of space at time 1 and a significantly decreased preference for the right side of space at time 2 compared with controls. Children with right hemisphere lesions showed a significantly decreased preference for the left side of space and a significantly increased preference for the right side of space compared with controls at time 1 and a significantly decreased preference for the left side of space and a significantly increased preference for the right side of space compared with controls at time 2. There were no significant within-subjects effects across time.

Conclusions

These data suggest that mechanisms of hemispatial inattention affect children early in the developmental process and that hemispatial inattention in children with both left and right hemisphere perinatal lesions likely persists at least through the early elementary school years.

中文翻译：

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围产期脑卒中患儿空间注意力不集中的纵向稳定性

背景

围产期脑梗塞（病变）后的儿童可能会出现对侧半侧空间注意力不集中的迹象，并且证据显示出与成人不同的模式。这项研究是对围产期梗塞儿童的纵向分析，目的是确定左半球或右半球病变儿童注意力不集中的模式，以及这种模式是否随着时间的推移而出现变化的迹象。

方法

21 名左侧半球损伤儿童、9 名右侧半球损伤儿童和 80 名神经健康对照儿童在两个不同的时间点接受了婴幼儿忽视任务。在时间 1，中位年龄为 1.54 岁（四分位距 [IQR] = 0.92 至 2.29）。在时间 2，中位年龄为 3.25 岁（IQR  = 2.23 至 5.00）。开发了一个标准化的评分系统来比较孩子们对空间左侧和右侧的偏好。

结果

与对照组相比，患有左半球病变的儿童在时间 1 对空间左侧的偏好显着增加，对空间右侧的偏好略有下降，在时间 2 对空间右侧的偏好显着降低。与对照组相比，患有右半球病变的儿童在时间 1 时对空间左侧的偏好显着降低，对空间右侧的偏好显着增加，对空间左侧的偏好显着降低，对空间的偏好显着增加空间的右侧与时间 2 的对照相比。随着时间的推移，没有显着的受试者内效应。

结论

这些数据表明，半侧空间注意力不集中的机制会在发育过程的早期影响儿童，并且左右半球围产期病变儿童的半侧空间注意力不集中可能至少会持续到小学早期。